Literature DB >> 28133058

[Radical Chemoradiotherapy for Recurrent Esophageal Cancer after Curative Esophagectomy].

Tetsushi Nakajima1, Takashi Ogata, Takuma Nomiya, Tetsuo Nonaka, Yuko Nakayama, Kazuki Kano, Yukio Maezawa, Kenki Segami, Kousuke Ikeda, Tsutomu Sato, Haruhiko Cho, Takaki Yoshikawa.   

Abstract

Recurrent esophageal cancer has a poor prognosis.However, we sometimes encounter cases with long-term survival after radical treatment for recurrent esophageal cancer.We perform radical chemoradiotherapy aggressively when recurrent esophageal cancer is present in a limited area and is sufficiently localized to be treated by radiation therapy.From June 2010 to December 2014, 150 patients underwent curative esophagectomy for esophageal cancer.Forty -one cases relapsed and we treated 13 of them with radical chemoradiotherapy.Complete response(CR), non-CR/non-PD, and progressive disease(PD) were observed in 5, 6, and 2 cases, respectively.The CR rate was 38.4%.The median survival time from recurrence was 500± 39.7 days, and the 1-year and 3-year survival rates were 84.6% and 28.7%, respectively. Four out of 5 CR cases were single site recurrences.The other case was multiple and regrowth of the cancer was identified 253 days after the CR.These results suggest that radical chemoradiotherapy for recurrent esophageal cancer after curative esophagectomy can achieve long time survival, especially in cases with single site lymph node recurrence.

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Year:  2016        PMID: 28133058

Source DB:  PubMed          Journal:  Gan To Kagaku Ryoho        ISSN: 0385-0684


  1 in total

1.  External beam radiotherapy with or without californium-252 neutron brachytherapy for treatment of recurrence after definitive chemoradiotherapy.

Authors:  Wen-An Wu; Yi-Ping Yang; Jing Liang; Jin Zhao; Jian-Sheng Wang; Jia Zhang
Journal:  Sci Rep       Date:  2020-12-01       Impact factor: 4.379

  1 in total

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