Literature DB >> 28132805

Highly expressed long non-coding RNA FOXD2-AS1 promotes non-small cell lung cancer progression via Wnt/β-catenin signaling.

Lin Rong1, Ruixing Zhao1, Jinxiu Lu2.   

Abstract

Non-small cell lung cancer (NSCLC) is one of the most common and aggressive tumors around the world. Long-noncoding RNAs (lncRNAs) have been recently shown to play important roles in regulating numerous biological processes including tumor progression. However, the role of lncRNA FOXD2-AS1 in NSCLC remains unclear. In this study, we found that lncRNA FOXD2-AS1 is significantly up-regulated in NSCLC tissues. Loss- and gain-function assays revealed that FOXD2-AS1 promotes NSCLC cell growth and NSCLC tumor progression. Furthermore, we also revealed that FOXD2-AS1 modulates Wnt/β-catenin signaling in NSCLC cells. Taken together, we conclude that lncRNA FOXD2-AS1 promotes NSCLC progression though Wnt/β-catenin signaling. These results suggest that lncRNA FOXD2-AS1 might act as a novel therapeutic target for NSCLC treatment.
Copyright © 2017 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  FOXD2-AS1; NSCLC; Wnt/β-catenin signaling; lncRNA

Mesh：

Substances：

Year:  2017        PMID： 28132805     DOI： 10.1016/j.bbrc.2017.01.141

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  22 in total

1.  EGR1-induced upregulation of lncRNA FOXD2-AS1 promotes the progression of hepatocellular carcinoma via epigenetically silencing DKK1 and activating Wnt/β-catenin signaling pathway.

Authors:  Ting Lei; Xiaodong Zhu; Kai Zhu; Fuxin Jia; Siqiao Li
Journal:  Cancer Biol Ther       Date:  2019-03-31       Impact factor: 4.742

2.  Long non-coding RNA FOXD2-AS1 promotes proliferation, migration and invasion of ovarian cancer cells via regulating the expression of miR-4492.

Authors:  Jianfen Gao; Faqin Liu; Xia Zhao; Ping Zhang
Journal:  Exp Ther Med       Date:  2021-02-01       Impact factor: 2.447

3.  Upregulation of the long non-coding RNA FOXD2-AS1 is correlated with tumor progression and metastasis in papillary thyroid cancer.

Authors:  Hongqiang Li; Qicai Han; Yali Chen; Xiaolong Chen; Runsheng Ma; Qungang Chang; Detao Yin
Journal:  Am J Transl Res       Date:  2019-09-15       Impact factor: 4.060

Review 4.  'Lnc'-ing Wnt in female reproductive cancers: therapeutic potential of long non-coding RNAs in Wnt signalling.

Authors:  Mei S Ong; Wanpei Cai; Yi Yuan; Hin C Leong; Tuan Z Tan; Asad Mohammad; Ming L You; Frank Arfuso; Boon C Goh; Sudha Warrier; Gautam Sethi; Nicholas S Tolwinski; Peter E Lobie; Celestial T Yap; Shing C Hooi; Ruby Y Huang; Alan P Kumar
Journal:  Br J Pharmacol       Date:  2017-08-23       Impact factor: 8.739

Review 5.  Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape.

Authors:  Qinghua Wu; Li You; Eugenie Nepovimova; Zbynek Heger; Wenda Wu; Kamil Kuca; Vojtech Adam
Journal:  J Hematol Oncol       Date:  2022-06-03       Impact factor: 23.168

6.  Long non-coding RNA CRYBG3 regulates glycolysis of lung cancer cells by interacting with lactate dehydrogenase A.

Authors:  Huaiyuan Chen; Hailong Pei; Wentao Hu; Ji Ma; Jian Zhang; Weidong Mao; Jing Nie; Chao Xu; Bingyan Li; Tom K Hei; Chang Wang; Guangming Zhou
Journal:  J Cancer       Date:  2018-06-23       Impact factor: 4.207

7.  The fibrotic microenvironment promotes the metastatic seeding of tumor cells into the lungs via mediating the ZEB1-AS1/miR-200b-3p/ZEB1 signaling.

Authors:  Jingjing Liu; Liming Cao; Jie Meng; Yuanyuan Li; Pengbo Deng; Pinhua Pan; Chengping Hu; Huaping Yang
Journal:  Cell Cycle       Date:  2020-10-05       Impact factor: 5.173

8.  Long non-coding RNA XIST promotes cell growth and metastasis through regulating miR-139-5p mediated Wnt/β-catenin signaling pathway in bladder cancer.

Authors:  Yangyang Hu; Chao Deng; He Zhang; Jing Zhang; Bo Peng; Chuanyi Hu
Journal:  Oncotarget       Date:  2017-10-10

Review 9.  Long non-coding RNAs associated with non-small cell lung cancer.

Authors:  Yuting Zhan; Hongjing Zang; Juan Feng; Junmi Lu; Lingjiao Chen; Songqing Fan
Journal:  Oncotarget       Date:  2017-08-09

10.  Long non-coding RNAs function as novel predictors and targets of non-small cell lung cancer: a systematic review and meta-analysis.

Authors:  Yanlu Xiong; Tao Wang; Mingxing Wang; Jinbo Zhao; Xiaofei Li; Zhipei Zhang; Yongsheng Zhou; Jiabao Liu; Lintao Jia; Yong Han
Journal:  Oncotarget       Date:  2018-01-04
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