| Literature DB >> 28132438 |
A C Böhmer1,2, J Schumacher1.
Abstract
Gastroesophageal reflux disease (GERD) is associated with obesity and hiatal hernia, and often precedes the development of Barrett's esophagus (BE) and esophageal adenocarcinoma (EA). Epidemiological studies show that the global prevalence of GERD is increasing. GERD is a multifactorial disease with a complex genetic architecture. Genome-wide association studies (GWAS) have provided initial insights into the genetic background of GERD. The present review summarizes current knowledge of the genetics of GERD and a possible genetic overlap between GERD and BE and EA. The review discusses genes and cellular pathways that have been implicated through GWAS, and provides an outlook on how future molecular research will enhance understanding of GERD pathophysiology.Entities:
Keywords: barrett’s esophagus; esophageal adenocarcinoma; gastroesophageal reflux disease; genome-wide association studies, shared genetic etiology
Mesh：
Year: 2017 PMID： 28132438 DOI： 10.1111/nmo.13017
Source DB: PubMed Journal: Neurogastroenterol Motil ISSN： 1350-1925 Impact factor: 3.598