Maude Vecten1,2, Hélène Martel3, Jean-Paul Casalta1,2, Sandrine Hubert3, Hubert Lepidi1, Gilbert Habib3, Didier Raoult1,2, Frédérique Gouriet4,5. 1. Faculté de Médecine, URMITE, Aix-Marseille Université, UM63, CNRS 7278, IRD 198, INSERM 1095, IHU Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France. 2. Pôle de Maladies Infectieuses, Hôpital de la Timone, Rue St Pierre, 13385, Marseille, France. 3. Department of Cardiology, Centre Hospitalier Universitaire, Hôpital de La Timone, AP-HM, Aix-Marseille University, Marseille, France. 4. Faculté de Médecine, URMITE, Aix-Marseille Université, UM63, CNRS 7278, IRD 198, INSERM 1095, IHU Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France. frederique.gouriet@ap-hm.fr. 5. Pôle de Maladies Infectieuses, Hôpital de la Timone, Rue St Pierre, 13385, Marseille, France. frederique.gouriet@ap-hm.fr.
Abstract
INTRODUCTION: Neisseria macacae is a Gram-negative diplococcus, found in the oropharynx of healthy Rhesus Monkeys. Infections caused by N. macacae in humans are extremely rare. CASE PRESENTATION: We present here the first case of N. macacae infective endocarditis in a 65-year-old man with a native aortic valve infection complicated by a peri-aortic abscess. N. macacae was isolated from blood culture and was found on the cardiac valve using 16S rDNA detection. Despite an appropriate antibiotic therapy, and aortic homograft replacement, and mitral repair, the patient died 4 days after surgery from a massive hemorrhagic stroke.
INTRODUCTION:Neisseria macacae is a Gram-negative diplococcus, found in the oropharynx of healthy Rhesus Monkeys. Infections caused by N. macacae in humans are extremely rare. CASE PRESENTATION: We present here the first case of N. macacaeinfective endocarditis in a 65-year-old man with a native aortic valve infection complicated by a peri-aortic abscess. N. macacae was isolated from blood culture and was found on the cardiac valve using 16S rDNA detection. Despite an appropriate antibiotic therapy, and aortic homograft replacement, and mitral repair, the patient died 4 days after surgery from a massive hemorrhagic stroke.
Authors: Nathan J Weyand; Anne M Wertheimer; Theodore R Hobbs; Jennifer L Sisko; Nyiawung A Taku; Lindsay D Gregston; Susan Clary; Dustin L Higashi; Nicolas Biais; Lewis M Brown; Shannon L Planer; Alfred W Legasse; Michael K Axthelm; Scott W Wong; Magdalene So Journal: Proc Natl Acad Sci U S A Date: 2013-02-04 Impact factor: 11.205
Authors: Julia S Bennett; Keith A Jolley; Sarah G Earle; Craig Corton; Stephen D Bentley; Julian Parkhill; Martin C J Maiden Journal: Microbiology (Reading) Date: 2012-03-15 Impact factor: 2.777