Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Rab10 Disruption Results in Delayed OPC Maturation.

Literature DB >> 28132130

Rab10 Disruption Results in Delayed OPC Maturation.

Zhao-Huan Zhang^1,2, Wei-Qian Zhao¹, Fan-Fei Ma¹, Hui Zhang¹, Xiao-Hui Xu³.

Abstract

Oligodendrocyte precursor cell (OPC) maturation requires membrane addition for myelin sheath formation. Since the Rab system has been shown to contribute to membrane addition in other cell types, in this study, we explored the role of Rab in OPC maturation. SiRNA and shRNA techniques and conditional knockout mice provided in vitro and in vivo evidence that Rab10 is involved in OPC maturation and may affect myelination during OPC development.

Entities: Gene Species

Keywords: MBP; Maturation; Membrane addition; OPC; Rab10

Mesh：

Substances：

Year: 2017 PMID： 28132130 DOI： 10.1007/s10571-017-0465-5

Source DB: PubMed Journal: Cell Mol Neurobiol ISSN： 0272-4340 Impact factor: 5.046

27 in total

Review 1. The ras protein family: evolutionary tree and role of conserved amino acids.

Authors: A Valencia; P Chardin; A Wittinghofer; C Sander
Journal: Biochemistry Date: 1991-05-14 Impact factor: 3.162

2. SNARE complex proteins, including the cognate pair VAMP-2 and syntaxin-4, are expressed in cultured oligodendrocytes.

Authors: D L Madison; W H Krueger; D Cheng; B D Trapp; S E Pfeiffer
Journal: J Neurochem Date: 1999-03 Impact factor: 5.372

3. WNK1 is involved in Nogo66 inhibition of OPC differentiation.

Authors: Zhao-Huan Zhang; Jiao-Jiao Li; Qing-Jin Wang; Wei-Qian Zhao; Jiang Hong; Shu-jie Lou; Xiao-Hui Xu
Journal: Mol Cell Neurosci Date: 2015-03-06 Impact factor: 4.314

4. MARCKS regulates membrane targeting of Rab10 vesicles to promote axon development.

Authors: Xiao-Hui Xu; Cai-Yun Deng; Yang Liu; Miao He; Jian Peng; Tong Wang; Lei Yuan; Zhi-Sheng Zheng; Perry J Blackshear; Zhen-Ge Luo
Journal: Cell Res Date: 2014-03-25 Impact factor: 25.617

5. Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination.

Authors: Martha Zeger; Greg Popken; Jihui Zhang; Shouhong Xuan; Q Richard Lu; Markus H Schwab; Klaus-Armin Nave; David Rowitch; A Joseph D'Ercole; Ping Ye
Journal: Glia Date: 2007-03 Impact factor: 7.452

Rab10 Disruption Results in Delayed OPC Maturation.

Review 1. The ras protein family: evolutionary tree and role of conserved amino acids.

2. SNARE complex proteins, including the cognate pair VAMP-2 and syntaxin-4, are expressed in cultured oligodendrocytes.

3. WNK1 is involved in Nogo66 inhibition of OPC differentiation.

4. MARCKS regulates membrane targeting of Rab10 vesicles to promote axon development.

5. Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination.

6. Lgl1 activation of rab10 promotes axonal membrane trafficking underlying neuronal polarization.

7. Folding and function of the myelin proteins from primary sequence data.

8. Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination.

Review 9. In vitro modeling of central nervous system myelination and remyelination.

10. Targeted disruption of Rab10 causes early embryonic lethality.

1. MARCKS is Necessary for Oligodendrocyte Precursor Cell Maturation.