Gabie K B Ong1, Tobi J Reidy2, Matthew D Huk2, Frederick R Lane3. 1. St. Vincent's Hospital, 2001 W. 86th St., Indianapolis, IN, 46260, USA. 2. Kendrick Colon and Rectal Center, 5255 E. Stop 11 Ave., Suite 250, Indianapolis, IN, 46237, USA. 3. Kendrick Colon and Rectal Center, 5255 E. Stop 11 Ave., Suite 250, Indianapolis, IN, 46237, USA. Electronic address: fredl422@aol.com.
Abstract
BACKGROUND: Clostridium difficile colitis is an important cause of morbidity and mortality in the surgical patient. In recent years, Clostridium difficile infections have shown marked increases in frequency, severity, and resistance to standard treatment. With urgent operative interventions and novel endoscopic approaches, pseudomembranous colitis is being seen more commonly in surgical practices. DATA SOURCES: In this paper, we will review a number of papers from the literature. We will discuss the epidemiology, evaluation and treatment of Clostridium difficile infection. Fulminant colitis may require emergency operation. For the surgical endoscopist, fecal microbiota transplantation restores the gastrointestinal flora, and has been shown to be effective in more than 80% of patients. CONCLUSION: Clostridium difficile infection is a major cause of healthcare-related diarrhea leading to increased morbidity and mortality in surgical patients. Increases in failure rates and resistance to current treatments are clinical and economic challenges in the healthcare situation.
BACKGROUND:Clostridium difficilecolitis is an important cause of morbidity and mortality in the surgical patient. In recent years, Clostridium difficile infections have shown marked increases in frequency, severity, and resistance to standard treatment. With urgent operative interventions and novel endoscopic approaches, pseudomembranous colitis is being seen more commonly in surgical practices. DATA SOURCES: In this paper, we will review a number of papers from the literature. We will discuss the epidemiology, evaluation and treatment of Clostridium difficileinfection. Fulminant colitis may require emergency operation. For the surgical endoscopist, fecal microbiota transplantation restores the gastrointestinal flora, and has been shown to be effective in more than 80% of patients. CONCLUSION:Clostridium difficileinfection is a major cause of healthcare-related diarrhea leading to increased morbidity and mortality in surgical patients. Increases in failure rates and resistance to current treatments are clinical and economic challenges in the healthcare situation.
Authors: Laurent Bouillaut; Thomas Dubois; Michael B Francis; Nadine Daou; Marc Monot; Joseph A Sorg; Abraham L Sonenshein; Bruno Dupuy Journal: Mol Microbiol Date: 2019-04-02 Impact factor: 3.501
Authors: A Aliramezani; M Talebi; A Baghani; M Hajabdolbaghi; M Salehi; A Abdollahi; S Afhami; M Marjani; F Golbabaei; M A Boroumand; A Sarrafnejad; M Yaseri; S Ghourchian; M Douraghi Journal: New Microbes New Infect Date: 2018-08-02