Myrlene Gee1, Juergen Dukart2, Bogdan Draganski3, W R Wayne Martin4, Derek Emery5, Richard Camicioli6. 1. Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada. 2. F. Hoffmann-LaRoche, Roche Innovation Centre, Basel, Switzerland; Laboratoire de Recherche en Neuroimagerie (LREN), Departement des Neurosciences Cliniques, Centre Hopitalier Universitaire Vaudois (CHUV), Universite de Lausanne, 1011 Lausanne, Switzerland. 3. Laboratoire de Recherche en Neuroimagerie (LREN), Departement des Neurosciences Cliniques, Centre Hopitalier Universitaire Vaudois (CHUV), Universite de Lausanne, 1011 Lausanne, Switzerland. 4. Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada. 5. Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada; Department of Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada. 6. Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada. Electronic address: rcamicio@ualberta.ca.
Abstract
BACKGROUND: Parkinson's disease (PD), characterized by motor dysfunction and cognitive decline, may demonstrate specific patterns of brain atrophy. Although cross-sectional magnetic resonance imaging (MRI) studies show correlation between regional brain volume loss and cognitive impairment, there is only scarce evidence from longitudinal studies validating the link between cognition and brain anatomy in PD. OBJECTIVE: To test the relationship between magnitude and spatial extent of atrophy in PD patients with progressive, significant cognitive decline and dementia (PDD). METHODS: We followed thirty-three initially non-demented patients with prevalent PD for three years while monitoring cognitive function and brain atrophy. Longitudinally acquired T1-weighted magnetic resonance images were analyzed in the voxel-based morphometry framework of SPM. RESULTS: Groups did not differ significantly with respect to age or gender. More males developed PDD (7 males, 3 females) compared to those remaining intact (12 males, 11 females). Clusters of lower grey matter volume were found in PDD compared to PD in left uncus at baseline and an expanded region that included the left hippocampus and parahippocampal gyrus at 36months. The cognitive status by scan interaction showed differential changes between groups in the right insula. At a more liberal statistical threshold we observed changes in the right insula and bilateral hippocampi as well as the right cuneus additional to the lower brain stem. CONCLUSIONS: Region specific atrophy, consistent with the pattern of cortical Lewy body deposition seen in autopsy studies, can be detected with MRI in PD patients with significant cognitive decline. MRI may be useful for tracking cognitive decline in PD.
BACKGROUND:Parkinson's disease (PD), characterized by motor dysfunction and cognitive decline, may demonstrate specific patterns of brain atrophy. Although cross-sectional magnetic resonance imaging (MRI) studies show correlation between regional brain volume loss and cognitive impairment, there is only scarce evidence from longitudinal studies validating the link between cognition and brain anatomy in PD. OBJECTIVE: To test the relationship between magnitude and spatial extent of atrophy in PDpatients with progressive, significant cognitive decline and dementia (PDD). METHODS: We followed thirty-three initially non-demented patients with prevalent PD for three years while monitoring cognitive function and brain atrophy. Longitudinally acquired T1-weighted magnetic resonance images were analyzed in the voxel-based morphometry framework of SPM. RESULTS: Groups did not differ significantly with respect to age or gender. More males developed PDD (7 males, 3 females) compared to those remaining intact (12 males, 11 females). Clusters of lower grey matter volume were found in PDD compared to PD in left uncus at baseline and an expanded region that included the left hippocampus and parahippocampal gyrus at 36months. The cognitive status by scan interaction showed differential changes between groups in the right insula. At a more liberal statistical threshold we observed changes in the right insula and bilateral hippocampi as well as the right cuneus additional to the lower brain stem. CONCLUSIONS: Region specific atrophy, consistent with the pattern of cortical Lewy body deposition seen in autopsy studies, can be detected with MRI in PDpatients with significant cognitive decline. MRI may be useful for tracking cognitive decline in PD.
Authors: Sarah Genon; Tobias Wensing; Andrew Reid; Felix Hoffstaedter; Svenja Caspers; Christian Grefkes; Thomas Nickl-Jockschat; Simon B Eickhoff Journal: Neuroimage Date: 2017-05-25 Impact factor: 6.556
Authors: Juliette H Lanskey; Peter McColgan; Anette E Schrag; Julio Acosta-Cabronero; Geraint Rees; Huw R Morris; Rimona S Weil Journal: Brain Date: 2018-09-01 Impact factor: 13.501