Literature DB >> 28131136

Endothelin Signaling in Bone.

Jasmin Kristianto1, Michael G Johnson2, Rafia Afzal3, Robert D Blank4.   

Abstract

The endothelin (ET) system includes 3 small peptide hormones and a pair of G-protein-coupled receptors. This review first outlines the ET signaling pathway and ET metabolism. Next, it summarizes the role of ET1 signaling in craniofacial development. Then, it discusses observations relating ET signaling to osteoblastic and other osteosclerotic processes in cancer. Finally, it describes recent work in our laboratory that points to endothelin signaling as an upstream mediator of WNT signaling, promoting bone matrix synthesis and mineralization. It concludes with a statement of some remaining gaps in knowledge and proposals for future research. Published by Elsevier Inc.

Entities:  

Keywords:  Endothelin 1 signaling; Mechanotransduction; Micro-RNA; Osteogenesis; WNT Signaling

Mesh：

Substances：

Year:  2016        PMID： 28131136      PMCID： PMC5321647          DOI： 10.1016/j.ecl.2016.09.014

Source DB:  PubMed          Journal:  Endocrinol Metab Clin North Am        ISSN： 0889-8529            Impact factor:   4.741


  88 in total

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Authors:  Kimihiko Sawakami; Alexander G Robling; Minrong Ai; Nathaniel D Pitner; Dawei Liu; Stuart J Warden; Jiliang Li; Peter Maye; David W Rowe; Randall L Duncan; Matthew L Warman; Charles H Turner
Journal:  J Biol Chem       Date:  2006-06-20       Impact factor: 5.157

3.  Genetic analyses in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genes.

Authors:  Anne-Marie Sims; Neil Shephard; Kim Carter; Tracy Doan; Alison Dowling; Emma L Duncan; John Eisman; Graeme Jones; Geoffrey Nicholson; Richard Prince; Ego Seeman; Gethin Thomas; John A Wass; Matthew A Brown
Journal:  J Bone Miner Res       Date:  2008-04       Impact factor: 6.741

4.  The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression.

Authors:  A Inoue; M Yanagisawa; Y Takuwa; Y Mitsui; M Kobayashi; T Masaki
Journal:  J Biol Chem       Date:  1989-09-05       Impact factor: 5.157

Review 5.  Role of endothelin-1 in osteoblastic bone metastases.

Authors:  Theresa A Guise; Juan Juan Yin; Khalid S Mohammad
Journal:  Cancer       Date:  2003-02-01       Impact factor: 6.860

6.  Humeral hypertrophy in response to exercise.

Authors:  H H Jones; J D Priest; W C Hayes; C C Tichenor; D A Nagel
Journal:  J Bone Joint Surg Am       Date:  1977-03       Impact factor: 5.284

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Journal:  Cell       Date:  1998-05-29       Impact factor: 41.582

8.  Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength.

Authors:  Xiaodong Li; Michael S Ominsky; Qing-Tian Niu; Ning Sun; Betsy Daugherty; Diane D'Agostin; Carole Kurahara; Yongming Gao; Jin Cao; Jianhua Gong; Frank Asuncion; Mauricio Barrero; Kelly Warmington; Denise Dwyer; Marina Stolina; Sean Morony; Ildiko Sarosi; Paul J Kostenuik; David L Lacey; W Scott Simonet; Hua Zhu Ke; Chris Paszty
Journal:  J Bone Miner Res       Date:  2008-06       Impact factor: 6.741

9.  Lrp5 functions in bone to regulate bone mass.

Authors:  Yajun Cui; Paul J Niziolek; Bryan T MacDonald; Cassandra R Zylstra; Natalia Alenina; Daniel R Robinson; Zhendong Zhong; Susann Matthes; Christina M Jacobsen; Ronald A Conlon; Robert Brommage; Qingyun Liu; Faika Mseeh; David R Powell; Qi M Yang; Brian Zambrowicz; Han Gerrits; Jan A Gossen; Xi He; Michael Bader; Bart O Williams; Matthew L Warman; Alexander G Robling
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10.  Congenic Strains Confirm the Pleiotropic Effect of Chromosome 4 QTL on Mouse Femoral Geometry and Biomechanical Performance.

Authors:  Jasmin Kristianto; Suzanne J Litscher; Michael G Johnson; Forum Patel; Mital Patel; Jacqueline Fisher; Ryley K Zastrow; Abigail B Radcliff; Robert D Blank
Journal:  PLoS One       Date:  2016-02-05       Impact factor: 3.240
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Journal:  Bone Res       Date:  2022-01-25       Impact factor: 13.567

2.  Mir24-2-5p suppresses the osteogenic differentiation with Gnai3 inhibition presenting a direct target via inactivating JNK-p38 MAPK signaling axis.

Authors:  Li Meng; Lichan Yuan; Jieli Ni; Mengru Fang; Shuyu Guo; Huayang Cai; Jinwei Qin; Qi Cai; Mengnan Zhang; Fang Hu; Junqing Ma; Yang Zhang
Journal:  Int J Biol Sci       Date:  2021-10-17       Impact factor: 6.580

3.  Inhibiting Endothelin Receptors with Macitentan Strengthens the Bone Protective Action of RANKL Inhibition and Reduces Metastatic Dissemination in Osteosarcoma.

Authors:  Javier Muñoz-Garcia; Jorge William Vargas-Franco; Bénédicte Brounais-Le Royer; Denis Cochonneau; Jérôme Amiaud; Marie-Françoise Heymann; Dominique Heymann; Frédéric Lézot
Journal:  Cancers (Basel)       Date:  2022-03-30       Impact factor: 6.639

4.  Impaired SNF2L Chromatin Remodeling Prolongs Accessibility at Promoters Enriched for Fos/Jun Binding Sites and Delays Granule Neuron Differentiation.

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Journal:  Front Mol Neurosci       Date:  2021-07-06       Impact factor: 5.639

Review 5.  Cellular and Molecular Mediators of Bone Metastatic Lesions.

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Journal:  Int J Mol Sci       Date:  2018-06-08       Impact factor: 5.923
  5 in total

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