Xuan Sun1, Xu Tong1, Wai Ting Lo1, Dapeng Mo1, Feng Gao1, Ning Ma1, Bo Wang1, Zhongrong Miao2. 1. From the Department of Interventional Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.S., D.M., F.G., N.M., B.W., Z.M.); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, China (X.S., D.M., F.G., N.M., B.W., Z.M.); China National Clinical Research Center for Neurological Diseases Center of Stroke, Beijing (X.S., D.M., F.G., N.M., B.W., Z.M.); Beijing Institute for Brain Disorders, China (X.S., D.M., F.G., N.M., B.W., Z.M.); Department of Neurology, Tangshan Gongren Hospital, Hebei Medical University, China (X.T.); and Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China (W.T.L.). 2. From the Department of Interventional Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.S., D.M., F.G., N.M., B.W., Z.M.); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, China (X.S., D.M., F.G., N.M., B.W., Z.M.); China National Clinical Research Center for Neurological Diseases Center of Stroke, Beijing (X.S., D.M., F.G., N.M., B.W., Z.M.); Beijing Institute for Brain Disorders, China (X.S., D.M., F.G., N.M., B.W., Z.M.); Department of Neurology, Tangshan Gongren Hospital, Hebei Medical University, China (X.T.); and Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China (W.T.L.). zhongrongm@163.com.
Abstract
BACKGROUND AND PURPOSE: We aimed to explore the risk factors of subacute thrombosis (SAT) after intracranial stenting for patients with symptomatic intracranial arterial stenosis. METHODS: From January to December 2013, all symptomatic intracranial arterial stenosis patients who underwent intracranial stenting in Beijing Tiantan Hospital were prospectively registered into this study. Baseline clinical features and operative data were compared in patients who developed SAT with those who did not. Binary logistic regression model was used to determine the risk factors associated with SAT. RESULTS: Of the 221 patients enrolled, 9 (4.1%) cases had SAT 2 to 8 days after stenting. Binary logistic analysis showed that SAT was related with tandem stenting (odds ratio [OR], 11.278; 95% confidence interval [CI], 2.422-52.519) and antiplatelet resistance (aspirin resistance: OR, 6.267; 95% CI, 1.574-24.952; clopidogrel resistance: OR, 15.526; 95% CI, 3.105-77.626; aspirin and clopidogrel resistance: OR, 12.246; 95% CI, 2.932-51.147; and aspirin or clopidogrel resistance: OR, 11.340; 95% CI, 2.282-56.344). CONCLUSIONS: Tandem stenting and antiplatelet resistance might contribute to the development of SAT after intracranial stenting in patients with symptomatic intracranial arterial stenosis.
BACKGROUND AND PURPOSE: We aimed to explore the risk factors of subacute thrombosis (SAT) after intracranial stenting for patients with symptomatic intracranial arterial stenosis. METHODS: From January to December 2013, all symptomatic intracranial arterial stenosispatients who underwent intracranial stenting in Beijing Tiantan Hospital were prospectively registered into this study. Baseline clinical features and operative data were compared in patients who developed SAT with those who did not. Binary logistic regression model was used to determine the risk factors associated with SAT. RESULTS: Of the 221 patients enrolled, 9 (4.1%) cases had SAT 2 to 8 days after stenting. Binary logistic analysis showed that SAT was related with tandem stenting (odds ratio [OR], 11.278; 95% confidence interval [CI], 2.422-52.519) and antiplatelet resistance (aspirin resistance: OR, 6.267; 95% CI, 1.574-24.952; clopidogrel resistance: OR, 15.526; 95% CI, 3.105-77.626; aspirin and clopidogrel resistance: OR, 12.246; 95% CI, 2.932-51.147; and aspirin or clopidogrel resistance: OR, 11.340; 95% CI, 2.282-56.344). CONCLUSIONS: Tandem stenting and antiplatelet resistance might contribute to the development of SAT after intracranial stenting in patients with symptomatic intracranial arterial stenosis.