Yunmeng Yan1,2, Guangzhen Fu1,2, Yafei Ye1,2, Liang Ming1,2. 1. a Department of Clinical Laboratory , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , PR China. 2. b Department of Clinical Laboratory, Key Clinical Laboratory of Henan Province , Zhengzhou , PR China.
Abstract
OBJECTIVE: In order to summarize the role of exosomes in invasion and metastasis in gastric cancer (GC). MATERIAL: Exosomes are vesicles of endocytic origin ranging from 30 to 100 nm in size; they are composed of a lipid bilayer and contain DNA, mRNA, miRNA, circular RNA and multiple proteins. Recently, increasing evidence shows that exosomes play a crucial role in the tumorigenesis of GC. RESULTS: In this review, we focus on the latest findings on GC exosomes, mainly summarizing their role in invasion and metastasis in GC. Then, exosomes? potential functions as novel diagnostic and therapeutic biomarkers for GC are briefly discussed. At last, we prospect the clinical application perspective of exosomes in GC. CONCLUSIONS: Exosomes play a vital role in gastric cancer carcinogenesis and metastasis.
OBJECTIVE: In order to summarize the role of exosomes in invasion and metastasis in gastric cancer (GC). MATERIAL: Exosomes are vesicles of endocytic origin ranging from 30 to 100 nm in size; they are composed of a lipid bilayer and contain DNA, mRNA, miRNA, circular RNA and multiple proteins. Recently, increasing evidence shows that exosomes play a crucial role in the tumorigenesis of GC. RESULTS: In this review, we focus on the latest findings on GC exosomes, mainly summarizing their role in invasion and metastasis in GC. Then, exosomes? potential functions as novel diagnostic and therapeutic biomarkers for GC are briefly discussed. At last, we prospect the clinical application perspective of exosomes in GC. CONCLUSIONS: Exosomes play a vital role in gastric cancer carcinogenesis and metastasis.
Authors: María Fernanda González; Paula Díaz; Alejandra Sandoval-Bórquez; Daniela Herrera; Andrew F G Quest Journal: Int J Mol Sci Date: 2021-05-01 Impact factor: 5.923