| Literature DB >> 28128559 |
Annalisa Santucci1, Giulia Bernardini1, Daniela Braconi1, Elena Petricci1, Fabrizio Manetti1.
Abstract
This review mainly focuses on the physiological function of 4-hydroxyphenylpyruvate dioxygenase (HPPD), as well as on the development and application of HPPD inhibitors of several structural classes. Among them, one illustrative example is represented by compounds belonging to the class of triketone compounds. They were discovered by serendipitous observations on weed growth and were developed as bleaching herbicides. Informed reasoning on nitisinone (NTBC, 14), a triketone that failed to reach the final steps of the herbicidal design and development process, allowed it to become a curative agent for type I tyrosinemia (T1T) and to enter clinical trials for alkaptonuria. These results boosted the research of new compounds able to interfere with HPPD activity to be used for the treatment of the tyrosine metabolism-related diseases.Entities:
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Year: 2017 PMID： 28128559 DOI： 10.1021/acs.jmedchem.6b01395
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446