| Literature DB >> 28128064 |
Nancy Cortez-Espinosa1, Laura Perez-Campos Mayoral2, Eduardo Perez-Campos1, Hector Alejandro Cabrera Fuentes3, Eduardo Perez-Campos Mayoral1, Ruth Martínez-Cruz1, Socorro Pina Canseco1, Gabriel Mayoral Andrade1, Margarito Martinez Cruz4, Itandehui Gallegos Velasco1, Pedro Hernandez Cruz1.
Abstract
The association between type 2 diabetes mellitus (T2DM) and systemic inflammation may increase platelet reactivity and the accelerated development of vascular disease. Platelets are able to modulate the function of immune cells via the direct release of growth factors and pro-inflammatory chemokines through the production of microvesicles. The microvesicles trigger a transcellular delivery system of bioactive molecules to other cells acting as vectors in the exchange of biological information. Here, we consider the influence of platelets and platelet-derived microvesicles on cells of the immune system and the implications in the pathogenesis of T2DM. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.Entities:
Keywords: Platelets; diabetes; effectors; immune; inflammation; microvesicles
Mesh：
Substances：
Year: 2017 PMID： 28128064 DOI： 10.2174/1570161115666170126130309
Source DB: PubMed Journal: Curr Vasc Pharmacol ISSN： 1570-1611 Impact factor: 2.719