Literature DB >> 28128

Pharmacokinetics of sulphamethoxazole in man: effects of urinary pH and urine flow on metabolism and renal excretion of sulphamethoxazole and its metabolite N4-acetylsulphamethoxazole.

T B Vree, Y A Hekster, A M Baars, J E Damsma, E van der Kleijn.   

Abstract

A high performance liquid chromatography method for the determination of sulphamethoxazole and its metabolite N4-acetylsulphamethoxazole is described. The renal excretion rate and cumulative renal excretion of sulphamethoxazole is markedly influenced by urinary pH. With constant urinary pH, the renal excretion rate and the renal clearance of sulphamethoxazole is dependent on the urine flow. The renal clearance of the metabolite N4-acetylsulphamethoxazole is not influenced by urinary pH or urine flow. No clear acetylator phenotype could be detected in the group of volunteers studied. The extent of acetylation depends on the amount of sulphamethoxazole available for acetylation, thus indirectly on the urine pH and flow.

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Year:  1978        PMID： 28128     DOI： 10.2165/00003088-197803040-00005

Source DB:  PubMed          Journal:  Clin Pharmacokinet        ISSN： 0312-5963            Impact factor:   6.447


  26 in total

1.  Trimethoprim-sulfamethoxazole treatment of Pneumocystis carinii pneumonia in adults.

Authors:  W K Lau; L S Young
Journal:  N Engl J Med       Date:  1976-09-23       Impact factor: 91.245

2.  Control of urine pH and its effect on sulfaethidole excretion in humans.

Authors:  H B KOSTENBAUDER; J B PORTNOFF; J V SWINTOSKY
Journal:  J Pharm Sci       Date:  1962-11       Impact factor: 3.534

3.  Acetylation polymorphism of sulfapyridine in patients with ulcerative colitis and Crohn's disease.

Authors:  K M Das; M A Eastwood
Journal:  Clin Pharmacol Ther       Date:  1975-11       Impact factor: 6.875

4.  Relationship of sulfamethazine disposition kinetics to acetylator phenotype in man. A preliminary study.

Authors:  C J Chapron; M R Blum
Journal:  J Clin Pharmacol       Date:  1976-07       Impact factor: 3.126

5.  Quantitative determination of the bacteriostatically active fraction of sulfonamides and the sum of their inactive metabolites in the body fluids.

Authors:  J Rieder
Journal:  Chemotherapy       Date:  1972       Impact factor: 2.544

6.  Acetylation of procaine amide in man. A preliminary communication.

Authors:  E Karlsson; G Aberg; P Collste; L Molin; B Norlander; F Sjöqvist
Journal:  Eur J Clin Pharmacol       Date:  1975       Impact factor: 2.953

7.  Diurnal variations in the elimination rate of a sulfonamide in man.

Authors:  L Dettli; P Spring
Journal:  Helv Med Acta       Date:  1967-01

8.  Determination of trimethoprim and sulfamethoxazole (co-trimoxazole) in body fluids of man by means of high-performance liquid chromatography.

Authors:  T B Vree; Y A Hekster; A M Baars; J E Damsma; E V Kleijin
Journal:  J Chromatogr       Date:  1978-07-01

9.  Sulphadimidine acetylation test for classification of patients as slow or rapid inactivators of isoniazid.

Authors:  K V Rao; D A Mitchison; N G Nair; K Prema; S P Tripathy
Journal:  Br Med J       Date:  1970-08-29

10.  Treatment of Pneumocystis carinii pneumonitis with trimethoprim-sulfamethoxazole.

Authors:  W T Hughes; S Feldman; S K Sanyal
Journal:  Can Med Assoc J       Date:  1975-06-14       Impact factor: 8.262
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  8 in total

Review 1.  Clinical pharmacokinetics of enzyme inhibitors in antimicrobial chemotherapy.

Authors:  I D Watson; M J Stewart; D J Platt
Journal:  Clin Pharmacokinet       Date:  1988-09       Impact factor: 6.447

2.  Pharmacokinetics of N1-acetyl- and N4-acetylsulphamethoxazole in man.

Authors:  T B Vree; Y A Hekster; J E Damsma; E van der Kleijn; W J O'Reilly
Journal:  Clin Pharmacokinet       Date:  1979 Jul-Aug       Impact factor: 6.447

3.  Effects of methoxy groups in the NI-substituent of sulfonamides on the pathways of elimination in man. The acetylation-deacetylation equilibrium and mechanisms of renal excretion of sulfisomidine, sulfamethomidine and sulfadimethoxine.

Authors:  T B Vree; Y A Hekster; M W Tijhuis; M Baakman; M J Oosterbaan; E F Termond
Journal:  Pharm Weekbl Sci       Date:  1984-08-24

4.  The effect of the molecular structure of closely related N1-substituents of sulfonamides on the pathways of elimination in man. The acetylation-deacetylation equilibrium and renal clearance related to the structure of sulfadiazine, sulfamerazine and sulfadimidine.

Authors:  T B Vree; Y A Hekster; M W Tijhuis; M Baakman; T J Janssen; E F Termond
Journal:  Pharm Weekbl Sci       Date:  1983-04-29

5.  Deterioration of kidney function by high doses of co-trimoxazole in man.

Authors:  T B Vree; M Martea; Y A Hekster; E F Termond; R Van Klaveren; J W Lammers; J H Berden
Journal:  Pharm Weekbl Sci       Date:  1987-04-24

6.  Pharmacokinetics of sulfamethoxazole--trimethoprim combination during chronic peritoneal dialysis: effect of peritonitis.

Authors:  E Singlas; J N Colin; J Rottembourg; J P Meessen; A de Martin; M Legrain; P Simon
Journal:  Eur J Clin Pharmacol       Date:  1982       Impact factor: 2.953

7.  Determination of the acetylator phenotype and pharmacokinetics of some sulphonamides in man.

Authors:  T B Vree; W J O'Reilly; Y A Hekster; J E Damsma; E van der Kleijn
Journal:  Clin Pharmacokinet       Date:  1980 May-Jun       Impact factor: 6.447

8.  Pharmacokinetics and mechanism of renal excretion of short acting sulphonamides and N4-acetylsulphonamide derivatives in man. Structural requirements of sulphonamides for active tubular secretion.

Authors:  T B Vree; Y A Hekster; J E Damsma; M Tijhuis; W T Friesen
Journal:  Eur J Clin Pharmacol       Date:  1981       Impact factor: 2.953
  8 in total

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