Armando L Morera-Fumero1, Estefanía Díaz-Mesa2, Pedro Abreu-Gonzalez3, Lourdes Fernandez-Lopez4, Maria Del Rosario Cejas-Mendez2. 1. Departamento de Medicina Interna, Dermatología y Psiquiatría, Facultad de Medicina, Universidad de La Laguna (ULL), 38071. La Laguna, Santa Cruz de Tenerife, Islas Canarias, Spain; Consultoria Psiquiátrica, Santa Cruz de Tenerife, Islas Canarias, Spain. Electronic address: amorera@ull.es. 2. Servicio de Psiquiatría, Hospital Universitario de Canarias, Ofra. Santa Cruz de Tenerife, Spain. 3. Departmento de Ciencias Medicas Basicas: Unidad de Fisiología, Facultad de Medicina, Universidad de La Laguna (ULL), La Laguna, Santa Cruz de Tenerife, Islas Canarias, Spain. 4. Departamento de Medicina Interna, Dermatología y Psiquiatría, Facultad de Medicina, Universidad de La Laguna (ULL), 38071. La Laguna, Santa Cruz de Tenerife, Islas Canarias, Spain; Sociedad para la Investigación y Asistencia en Salud Mental, Santa Cruz de Tenerife, Spain.
Abstract
BACKGROUND: An oxidant-antioxidant system dysregulation has been described as a schizophrenia pathophysiological base. The total antioxidant capacity (TAC) is one measure of the antioxidant capacity of a system. Day/night concentration changes is a biological characteristic of hormones such as melatonin or cortisol. There is no information about TAC day/night changes in schizophrenia. AIMS: Studying the existence of a day/night TAC change in schizophrenia. METHOD: Forty-three DSM-IV paranoid schizophrenia inpatients participated in the study. Thirty healthy subjects matched by age and gender acted as control group. Blood was sampled at 12:00 and 00:00h the day after admission and the day before discharge. Serum TAC was measured by the ABTS radical cation technique and expressed in Trolox mmol/L. RESULTS: Patients had significantly lower TAC levels at admission and discharge (12:00 and 00:00) than controls. At admission patients had a TAC day/night change, with higher day-time than night-time levels (0.66±0.14 vs 0.60±0.15) as well as healthy subjects (0.83±0.07 vs 0.77±0.11). At discharge patients had a similar TAC level at 12:00 and 00:00 (0.64±0.15 vs 0.63±0.14). CONCLUSION: Schizophrenic patients present a deficit of the antioxidant system. The initial presence and the later absence of a day/night change deserves future studies.
BACKGROUND: An oxidant-antioxidant system dysregulation has been described as a schizophrenia pathophysiological base. The total antioxidant capacity (TAC) is one measure of the antioxidant capacity of a system. Day/night concentration changes is a biological characteristic of hormones such as melatonin or cortisol. There is no information about TAC day/night changes in schizophrenia. AIMS: Studying the existence of a day/night TAC change in schizophrenia. METHOD: Forty-three DSM-IV paranoid schizophrenia inpatients participated in the study. Thirty healthy subjects matched by age and gender acted as control group. Blood was sampled at 12:00 and 00:00h the day after admission and the day before discharge. Serum TAC was measured by the ABTS radical cation technique and expressed in Trolox mmol/L. RESULTS:Patients had significantly lower TAC levels at admission and discharge (12:00 and 00:00) than controls. At admission patients had a TAC day/night change, with higher day-time than night-time levels (0.66±0.14 vs 0.60±0.15) as well as healthy subjects (0.83±0.07 vs 0.77±0.11). At discharge patients had a similar TAC level at 12:00 and 00:00 (0.64±0.15 vs 0.63±0.14). CONCLUSION:Schizophrenicpatients present a deficit of the antioxidant system. The initial presence and the later absence of a day/night change deserves future studies.
Authors: Armando L Morera-Fumero; Estefanía Díaz-Mesa; Pedro Abreu-Gonzalez; Lourdes Fernandez-Lopez; Fernando Guillen-Pino Journal: PLoS One Date: 2017-12-08 Impact factor: 3.240
Authors: Armando L Morera-Fumero; Pedro Abreu-Gonzalez; Manuel Henry-Benitez; Lourdes Fernandez-Lopez; Estefania Diaz-Mesa; Maria Del Rosario Cejas-Mendez; Fernando Guillen-Pino Journal: Med Chem Date: 2018 Impact factor: 2.745