Literature DB >> 2812542

Kainic acid induces early and delayed degenerative neuronal changes in rat spinal cord.

J Hugon1, J M Vallat, P S Spencer, M J Leboutet, D Barthe.   

Abstract

Intrathecal injections of kainic acid and sodium chloride were performed in rats to study the cellular modifications observed in spinal cord. Early neuronal changes (2 and 24 h) associated dark and shrunken or swollen and vacuolated cytoplasms. Delayed (3, 6, 14 days) changes, mainly consisted in degenerative aspect of motoneurons with eccentric and indented nucleus, swollen cytoplasms with proximal neurite enlargements, the presence of 'lipofuscin-like' pigments, disorganized intracytoplasmic organelles and filament accumulations.

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Year:  1989        PMID： 2812542     DOI： 10.1016/0304-3940(89)90585-5

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  19 in total

1.  AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability.

Authors:  W Vandenberghe; E C Ihle; D K Patneau; W Robberecht; J R Brorson
Journal:  J Neurosci       Date:  2000-10-01       Impact factor: 6.167

2.  Neuroprotective potential of ionotropic glutamate receptor antagonists.

Authors:  Wojciech Danysz; Chris G Parsons
Journal:  Neurotox Res       Date:  2002-03       Impact factor: 3.911

3.  Marked synergism between mutant SOD1 and glutamate transport inhibition in the induction of motor neuronal degeneration in spinal cord slice cultures.

Authors:  Hong Z Yin; John H Weiss
Journal:  Brain Res       Date:  2012-02-09       Impact factor: 3.252

4.  Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons.

Authors:  Shyam D Rao; Hong Z Yin; John H Weiss
Journal:  J Neurosci       Date:  2003-04-01       Impact factor: 6.167

5.  AMPA receptor calcium permeability, GluR2 expression, and selective motoneuron vulnerability.

Authors:  W Vandenberghe; W Robberecht; J R Brorson
Journal:  J Neurosci       Date:  2000-01-01       Impact factor: 6.167

6.  AMPA exposures induce mitochondrial Ca(2+) overload and ROS generation in spinal motor neurons in vitro.

Authors:  S G Carriedo; S L Sensi; H Z Yin; J H Weiss
Journal:  J Neurosci       Date:  2000-01-01       Impact factor: 6.167

7.  Amyotrophic lateral sclerosis: glutamate dehydrogenase and transmitter amino acids in the spinal cord.

Authors:  S Malessa; P N Leigh; O Bertel; E Sluga; O Hornykiewicz
Journal:  J Neurol Neurosurg Psychiatry       Date:  1991-11       Impact factor: 10.154

8.  Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS.

Authors:  Hong Z Yin; Darryl T Tang; John H Weiss
Journal:  Exp Neurol       Date:  2007-07-24       Impact factor: 5.330

9.  Patterns of neuronal degeneration in the motor cortex of amyotrophic lateral sclerosis patients.

Authors:  K Nihei; A C McKee; N W Kowall
Journal:  Acta Neuropathol       Date:  1993       Impact factor: 17.088

10.  Experimental models for the study of neurodegeneration in amyotrophic lateral sclerosis.

Authors:  Luis B Tovar-Y-Romo; Luz Diana Santa-Cruz; Ricardo Tapia
Journal:  Mol Neurodegener       Date:  2009-07-20       Impact factor: 14.195
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