Literature DB >> 2812536

Autogenous oscillatory potentials in neurons of the guinea pig substantia nigra pars compacta in vitro.

K Fujimura1, Y Matsuda.   

Abstract

In spontaneously firing neurons of the guinea pig substantia nigra pars compacta (SNC) maintained in slices, blockade of the fast spikes by tetrodotoxin (TTX) revealed a slow oscillatory potential change, which was depressed by Cd2+, a Ca2+-channel blocker. The spontaneous firing was suppressed by the application of Ca2+-free saline, Cd2+ or Co2+, but not by nifedipine. These findings lend support to the view that the spontaneous firing of SNC neurons is produced by an intrinsic, Ca2+-dependent pacemaking process affected by Cd2+ but not by nifedipine.

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Year:  1989        PMID： 2812536     DOI： 10.1016/0304-3940(89)90328-5

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  21 in total

1.  Pacemaking in dopaminergic ventral tegmental area neurons: depolarizing drive from background and voltage-dependent sodium conductances.

Authors:  Zayd M Khaliq; Bruce P Bean
Journal:  J Neurosci       Date:  2010-05-26       Impact factor: 6.167

2.  Spontaneous activity of solitary dopaminergic cells of the retina.

Authors:  A Feigenspan; S Gustincich; B P Bean; E Raviola
Journal:  J Neurosci       Date:  1998-09-01       Impact factor: 6.167

Review 3.  Calcium Channel Antagonists as Disease-Modifying Therapy for Parkinson's Disease: Therapeutic Rationale and Current Status.

Authors:  Tara Swart; Michael J Hurley
Journal:  CNS Drugs       Date:  2016-12       Impact factor: 5.749

Review 4.  Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs.

Authors:  Hitoshi Morikawa; Richard A Morrisett
Journal:  Int Rev Neurobiol       Date:  2010       Impact factor: 3.230

5.  Electrophysiology of dopaminergic and non-dopaminergic neurones of the guinea-pig substantia nigra pars compacta in vitro.

Authors:  W H Yung; M A Häusser; J J Jack
Journal:  J Physiol       Date:  1991-05       Impact factor: 5.182

6.  Sodium dynamics underlying burst firing and putative mechanisms for the regulation of the firing pattern in midbrain dopamine neurons: a computational approach.

Authors:  C C Canavier
Journal:  J Comput Neurosci       Date:  1999-01       Impact factor: 1.621

7.  Cellular mechanisms underlying burst firing in substantia nigra dopamine neurons.

Authors:  Sarah N Blythe; David Wokosin; Jeremy F Atherton; Mark D Bevan
Journal:  J Neurosci       Date:  2009-12-09       Impact factor: 6.167

8.  Nonselective cation channels are essential for maintaining intracellular Ca2+ levels and spontaneous firing activity in the midbrain dopamine neurons.

Authors:  Shin Hye Kim; Yu Mi Choi; Jin Yong Jang; Sungkwon Chung; Yun Kyung Kang; Myoung Kyu Park
Journal:  Pflugers Arch       Date:  2007-05-10       Impact factor: 3.657

9.  Effects of dihydropyridine calcium antagonists on rat midbrain dopaminergic neurones.

Authors:  N B Mercuri; A Bonci; P Calabresi; F Stratta; A Stefani; G Bernardi
Journal:  Br J Pharmacol       Date:  1994-11       Impact factor: 8.739

10.  Nifedipine- and omega-conotoxin-sensitive Ca2+ conductances in guinea-pig substantia nigra pars compacta neurones.

Authors:  S Nedergaard; J A Flatman; I Engberg
Journal:  J Physiol       Date:  1993-07       Impact factor: 5.182
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