A J Sloane1, U S Nawab1, D Carola1, Z H Aghai1. 1. Division of Neonatology, Department of Pediatrics, Thomas Jefferson University/Nemours, Philadelphia, PA, USA.
Abstract
OBJECTIVE: To assess the utility of measuring direct bilirubin (DB) during the first 72 h of life in infants admitted to the neonatal intensive care unit (NICU). STUDY DESIGN: Infants born between May 2006 and June 2013, and admitted to the NICU were included. Abnormal DB was defined as: DB level⩾1 mg dl-1 with a corresponding TB of ⩽5 mg dl-1 or DB level >20% of the corresponding TB>5 mg dl-1. RESULTS: The DB levels were measured in 3715 infants during the first 72 h of life. Sixty-three infants (1.7%) had abnormal DB. In a number of infants with potentially treatable diseases (biliary atresia and choledochal cyst), the only abnormal finding was a mildly elevated DB (1 to 2 mg dl-1) during the first 3 days of life. In 22 infants (35%), the cause for high DB was unknown (16%) or not investigated (19%). CONCLUSIONS: Routine measurement of DB in neonates admitted to NICU may be helpful in identifying potentially treatable causes of cholestasis.
OBJECTIVE: To assess the utility of measuring direct bilirubin (DB) during the first 72 h of life in infants admitted to the neonatal intensive care unit (NICU). STUDY DESIGN:Infants born between May 2006 and June 2013, and admitted to the NICU were included. Abnormal DB was defined as: DB level⩾1 mg dl-1 with a corresponding TB of ⩽5 mg dl-1 or DB level >20% of the corresponding TB>5 mg dl-1. RESULTS: The DB levels were measured in 3715 infants during the first 72 h of life. Sixty-three infants (1.7%) had abnormal DB. In a number of infants with potentially treatable diseases (biliary atresia and choledochal cyst), the only abnormal finding was a mildly elevated DB (1 to 2 mg dl-1) during the first 3 days of life. In 22 infants (35%), the cause for high DB was unknown (16%) or not investigated (19%). CONCLUSIONS: Routine measurement of DB in neonates admitted to NICU may be helpful in identifying potentially treatable causes of cholestasis.
Authors: B Shneider; J Cronin; L Van Marter; E Maller; R Truog; M Jacobson; S Kevy Journal: J Pediatr Gastroenterol Nutr Date: 1991-10 Impact factor: 2.839
Authors: Virginia Moyer; Deborah K Freese; Peter F Whitington; Alan D Olson; Fred Brewer; Richard B Colletti; Melvin B Heyman Journal: J Pediatr Gastroenterol Nutr Date: 2004-08 Impact factor: 2.839