Literature DB >> 28123849

DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation.

Irlanda Peralta-Arrieta1, Daniel Hernández-Sotelo2, Yaneth Castro-Coronel3, Marco Antonio Leyva-Vázquez1, Berenice Illades-Aguiar1.   

Abstract

Altered promoter DNA methylation is one of the most important epigenetic abnormalities in human cancer. DNMT3B, de novo methyltransferase, is clearly related to abnormal methylation of tumour suppressor genes, DNA repair genes and its overexpression contributes to oncogenic processes and tumorigenesis in vivo. The purpose of this study was to assess the effect of the overexpression of DNMT3B in HaCaT cells on global gene expression and on the methylation of selected genes to the identification of genes that can be target of DNMT3B. We found that the overexpression of DNMT3B in HaCaT cells, modulate the expression of genes related to cancer, downregulated the expression of 151 genes with CpG islands and downregulated the expression of the VAV3 gene via methylation of its promoter. These results highlight the importance of DNMT3B in gene expression and human cancer.

Entities:  

Keywords:  CpG island; Methylation; VAV3; cancer; cancer-related genes; de novo methyltransferase; overexpression of DNMT3B

Year:  2017        PMID： 28123849      PMCID： PMC5250682     

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN： 2156-6976            Impact factor:   6.166


  52 in total

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Authors:  Megan Beetch; Cayla Boycott; Sadaf Harandi-Zadeh; Tony Yang; Benjamin J E Martin; Thomas Dixon-McDougall; Kevin Ren; Allison Gacad; John H Dupuis; Melissa Ullmer; Katarzyna Lubecka; Rickey Y Yada; Carolyn J Brown; LeAnn J Howe; Barbara Stefanska
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Review 3.  Concept of histone deacetylases in cancer: Reflections on esophageal carcinogenesis and treatment.

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