Literature DB >> 28123061

Detection of vulnerable neurons damaged by environmental insults in utero.

Masaaki Torii1,2,3,4, Masanori Sasaki5,6,7, Yu-Wen Chang5,6, Seiji Ishii1, Stephen G Waxman5,6, Jeffery D Kocsis5,6, Pasko Rakic8,4, Kazue Hashimoto-Torii9,2,3,4.   

Abstract

Development of prognostic biomarkers for the detection of prenatally damaged neurons before manifestations of postnatal disorders is an essential step for prevention and treatment of susceptible individuals. We have developed a versatile fluorescence reporter system in mice enabling detection of Heat Shock Factor 1 activation in response to prenatal cellular damage caused by exposure to various harmful chemical or physical agents. Using an intrautero electroporation-mediated reporter assay and transgenic reporter mice, we are able to identify neurons that survive prenatal exposure to harmful agents but remain vulnerable in postnatal life. This system may provide a powerful tool for exploring the pathogenesis and treatment of multiple disorders caused by exposure to environmental stress before symptoms become manifested, exacerbated, and/or irreversible.

Entities:  

Keywords:  cerebral cortex; development; environmental stress; heat shock signaling; reporter

Mesh：

Substances：

Year:  2017        PMID： 28123061      PMCID： PMC5338500          DOI： 10.1073/pnas.1620641114

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  33 in total

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Authors:  Richard Voellmy
Journal:  Cell Stress Chaperones       Date:  2004       Impact factor: 3.667

2.  Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling.

Authors:  Masaaki Torii; Kazue Hashimoto-Torii; Pat Levitt; Pasko Rakic
Journal:  Nature       Date:  2009-09-16       Impact factor: 49.962

Review 3.  Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.

Authors:  R I Morimoto
Journal:  Genes Dev       Date:  1998-12-15       Impact factor: 11.361

4.  Alcohol alters DNA methylation patterns and inhibits neural stem cell differentiation.

Authors:  Feng C Zhou; Yokesh Balaraman; MingXiang Teng; Yunlong Liu; Rabindra P Singh; Kenneth P Nephew
Journal:  Alcohol Clin Exp Res       Date:  2011-01-11       Impact factor: 3.455

Review 5.  Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development.

Authors:  Kaïs H Al-Gubory
Journal:  Reprod Biomed Online       Date:  2014-03-21       Impact factor: 3.828

Review 6.  Cognitive deficits in spinal cord injury: epidemiology and outcome.

Authors:  G N Davidoff; E J Roth; J S Richards
Journal:  Arch Phys Med Rehabil       Date:  1992-03       Impact factor: 3.966

7.  Differential activities of Sonic hedgehog mediated by Gli transcription factors define distinct neuronal subtypes in the dorsal thalamus.

Authors:  Kazue Hashimoto-Torii; Jun Motoyama; Chi-Chung Hui; Atsushi Kuroiwa; Masato Nakafuku; Kenji Shimamura
Journal:  Mech Dev       Date:  2003-10       Impact factor: 1.882

8.  Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders.

Authors:  Kazue Hashimoto-Torii; Masaaki Torii; Mitsuaki Fujimoto; Akira Nakai; Rachid El Fatimy; Valerie Mezger; Min J Ju; Seiji Ishii; Shih-Hui Chao; Kristen J Brennand; Fred H Gage; Pasko Rakic
Journal:  Neuron       Date:  2014-04-10       Impact factor: 17.173

9.  High-efficiency FLP and PhiC31 site-specific recombination in mammalian cells.

Authors:  Christopher S Raymond; Philippe Soriano
Journal:  PLoS One       Date:  2007-01-17       Impact factor: 3.240

10.  Characterizing HSF1 Binding and Post-Translational Modifications of hsp70 Promoter in Cultured Cortical Neurons: Implications in the Heat-Shock Response.

Authors:  Andrea V Gómez; Gonzalo Córdova; Roberto Munita; Guillermo E Parada; Álvaro P Barrios; Gonzalo I Cancino; Alejandra R Álvarez; María E Andrés
Journal:  PLoS One       Date:  2015-06-08       Impact factor: 3.240
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  10 in total

Review 1.  Cannabis and the Developing Brain: Insights into Its Long-Lasting Effects.

Authors:  Yasmin L Hurd; Olivier J Manzoni; Mikhail V Pletnikov; Francis S Lee; Sagnik Bhattacharyya; Miriam Melis
Journal:  J Neurosci       Date:  2019-10-16       Impact factor: 6.167

2.  Shining a light on early stress responses and late-onset disease vulnerability.

Authors:  Mark F Mehler
Journal:  Proc Natl Acad Sci U S A       Date:  2017-02-08       Impact factor: 11.205

Review 3.  Cellular stress mechanisms of prenatal maternal stress: Heat shock factors and oxidative stress.

Authors:  Jonathan Dowell; Benjamin A Elser; Rachel E Schroeder; Hanna E Stevens
Journal:  Neurosci Lett       Date:  2019-07-09       Impact factor: 3.046

4.  Tracking the Activation of Heat Shock Signaling in Cellular Protection and Damage.

Authors:  Shisui Torii; Pasko Rakic
Journal:  Cells       Date:  2022-05-05       Impact factor: 7.666

5.  Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling.

Authors:  Seiji Ishii; Masaaki Torii; Alexander I Son; Meenu Rajendraprasad; Yury M Morozov; Yuka Imamura Kawasawa; Anna C Salzberg; Mitsuaki Fujimoto; Kristen Brennand; Akira Nakai; Valerie Mezger; Fred H Gage; Pasko Rakic; Kazue Hashimoto-Torii
Journal:  Nat Commun       Date:  2017-05-02       Impact factor: 14.919

6.  Maternal diabetes and the risk of feeding and eating disorders in offspring: a national population-based cohort study.

Authors:  Hui Wang; Hua He; Yongfu Yu; Xiujuan Su; Fei Li; Jiong Li
Journal:  BMJ Open Diabetes Res Care       Date:  2020-10

Review 7.  Prenatal Drugs and Their Effects on the Developing Brain: Insights From Three-Dimensional Human Organoids.

Authors:  Isidora N Stankovic; Dilek Colak
Journal:  Front Neurosci       Date:  2022-03-25       Impact factor: 4.677

8.  Detection of local and remote cellular damage caused by spinal cord and peripheral nerve injury using a heat shock signaling reporter system.

Authors:  Kazue Hashimoto-Torii; Masanori Sasaki; Yu-Wen Chang; Hye Hwang; Stephen G Waxman; Jeffery D Kocsis; Pasko Rakic; Masaaki Torii
Journal:  IBRO Rep       Date:  2018-11-06

Review 9.  Prenatal Environment That Affects Neuronal Migration.

Authors:  Hye M Hwang; Ray Y Ku; Kazue Hashimoto-Torii
Journal:  Front Cell Dev Biol       Date:  2019-07-17

10.  Kcnn2 blockade reverses learning deficits in a mouse model of fetal alcohol spectrum disorders.

Authors:  Shahid Mohammad; Stephen J Page; Li Wang; Seiji Ishii; Peijun Li; Toru Sasaki; Aiesha Basha; Anna Salzberg; Zenaide Quezado; Fumiaki Imamura; Hirotaka Nishi; Keiichi Isaka; Joshua G Corbin; Judy S Liu; Yuka Imamura Kawasawa; Masaaki Torii; Kazue Hashimoto-Torii
Journal:  Nat Neurosci       Date:  2020-03-16       Impact factor: 24.884
  10 in total

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