Literature DB >> 2812248

Combining CNS transplantation and gene transfer.

X O Breakefield1.   

Abstract

The applications of brain grafting for delivery of neuroactive substances to the brain can be increased dramatically by genetic modification of grafted cells. For example, cultured cells infected with retroviral vectors containing the "gene" for nerve growth factor and grafted into the CNS can effect NGF-dependent survival of cholinergic neurons.

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Year:  1989        PMID： 2812248     DOI： 10.1016/0197-4580(89)90167-x

Source DB:  PubMed          Journal:  Neurobiol Aging        ISSN： 0197-4580            Impact factor:   4.673


  2 in total

1.  Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington's disease.

Authors:  D F Emerich; M D Lindner; S R Winn; E Y Chen; B R Frydel; J H Kordower
Journal:  J Neurosci       Date:  1996-08-15       Impact factor: 6.167

2.  Herpesvirus-mediated gene delivery into the rat brain: specificity and efficiency of the neuron-specific enolase promoter.

Authors:  J K Andersen; D M Frim; O Isacson; X O Breakefield
Journal:  Cell Mol Neurobiol       Date:  1993-10       Impact factor: 5.046
  2 in total

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