Lihua Hong1, Yu Wang2, Lin Wang3, Hong Zhang4, Hui Na5, Zhimin Zhang6. 1. Endodontics Department of Stomatological Hospital, Jilin University, Changchun 130021, PR China; Alan G. MacDiarmid Institute, College of Chemistry, Jilin University, Changchun 130012, PR China. 2. Endoscopy Center Pathological Room, First Clinical Hospital of Bethune Medical, Jilin University, Changchun 130021, PR China. 3. VIP Department of Stomatological Hospital, Jilin University, Changchun 130021, PR China. 4. Endodontics Department of Stomatological Hospital, Jilin University, Changchun 130021, PR China. 5. Alan G. MacDiarmid Institute, College of Chemistry, Jilin University, Changchun 130012, PR China. Electronic address: huina@jlu.edu.cn. 6. Endodontics Department of Stomatological Hospital, Jilin University, Changchun 130021, PR China. Electronic address: zhangzm1964@sina.com.
Abstract
OBJECTIVE: In this study, we designed and synthesized a novel macromolecule (tetramethyl bisphenol F acrylate, TMBPF-Ac) with low viscosity, excellent mechanical properties, and good biocompatibility. It could be used as a monomer for dental resin composites, which could reduce the risk of human exposure to bisphenol A derivatives in the oral environment. In addition, the monomer could be used without diluent, thereby avoiding the negative effect of a diluent METHODS: TMBPF-Ac was synthesized by a multistep condensation reaction. Its structure was confirmed by 1H NMR spectra. Different resin mixtures were prepared, and then a number of performance and cytotoxicity tests were performed on these specimens. RESULTS: 1H NMR spectra showed that the structure of TMBPF-Ac was in accordance with the design. The viscosity of TMBPF-Ac was obviously lower than that of bisphenol-A diglycidyl methacrylate. The three kinds of resins used in this study were in line with ISO 4049:2009 and ISO 10993-5:2009. TMBPF-Ac-based resin had better physical and biological properties.
OBJECTIVE: In this study, we designed and synthesized a novel macromolecule (tetramethyl bisphenol F acrylate, TMBPF-Ac) with low viscosity, excellent mechanical properties, and good biocompatibility. It could be used as a monomer for dental resin composites, which could reduce the risk of human exposure to bisphenol A derivatives in the oral environment. In addition, the monomer could be used without diluent, thereby avoiding the negative effect of a diluent METHODS:TMBPF-Ac was synthesized by a multistep condensation reaction. Its structure was confirmed by 1H NMR spectra. Different resin mixtures were prepared, and then a number of performance and cytotoxicity tests were performed on these specimens. RESULTS:1H NMR spectra showed that the structure of TMBPF-Ac was in accordance with the design. The viscosity of TMBPF-Ac was obviously lower than that of bisphenol-A diglycidyl methacrylate. The three kinds of resins used in this study were in line with ISO 4049:2009 and ISO 10993-5:2009. TMBPF-Ac-based resin had better physical and biological properties.