H-M Zhang1, Q-D Qiao, H-F Xie, J-X Wei. 1. Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. lchlv439@sina.com.
Abstract
OBJECTIVE: Breast cancer metastasis suppressor 1 (BRMS1) was originally identified as a metastasis suppressor gene in human breast cancer. MATERIALS AND METHODS: A recent study has established an association between BRMS1 with the clinical stage and different pathology grades of prostate cancer. However, whether BRMS1 plays a role in prostate cancer has not been elucidated. RESULTS: In this study, we found that overexpression of BRMS1 in PC-3 cells induced apoptosis and inhibited invasion; moreover, we found that overexpression BRMS1 was associated with the suppressed expression of EMMPRIN. CONCLUSIONS: Taken together, our results show that BRMS1 may suppress progression and metastasis of prostate cancer through modulating EMMPRIN expression.
OBJECTIVE:Breast cancer metastasis suppressor 1 (BRMS1) was originally identified as a metastasis suppressor gene in humanbreast cancer. MATERIALS AND METHODS: A recent study has established an association between BRMS1 with the clinical stage and different pathology grades of prostate cancer. However, whether BRMS1 plays a role in prostate cancer has not been elucidated. RESULTS: In this study, we found that overexpression of BRMS1 in PC-3 cells induced apoptosis and inhibited invasion; moreover, we found that overexpression BRMS1 was associated with the suppressed expression of EMMPRIN. CONCLUSIONS: Taken together, our results show that BRMS1 may suppress progression and metastasis of prostate cancer through modulating EMMPRIN expression.
Authors: Rosalyn C Zimmermann; Mihaela E Sardiu; Christa A Manton; Md Sayem Miah; Charles A S Banks; Mark K Adams; Devin C Koestler; Douglas R Hurst; Mick D Edmonds; Michael P Washburn; Danny R Welch Journal: PLoS One Date: 2021-11-17 Impact factor: 3.752