PURPOSE AND OBJECTIVE: Improved prognosis for patients with peripheral neuroblastic tumors (PNB) depends on enhanced pretreatment risk stratification combined with research into new therapeutic targets. This study investigated the potential contribution of extracellular matrix (ECM) elements toward this endeavor. METHODS: We characterized certain elements such as reticulin fibers, collagen type I fibers, and elastic fibers by digital pathology in almost 400 untreated PNB. RESULTS: A reticular and poorly porous ECM was identified in neuroblastomas (NBs) from patients with clinical and biological features associated with poor prognosis compared with a loose and permeable matrix found in NBs of the favorable cohort. CONCLUSIONS: Aggressiveness patterns of ECM can be accurately determined by morphometric tools and could become candidate elements for novel therapies.
PURPOSE AND OBJECTIVE: Improved prognosis for patients with peripheral neuroblastic tumors (PNB) depends on enhanced pretreatment risk stratification combined with research into new therapeutic targets. This study investigated the potential contribution of extracellular matrix (ECM) elements toward this endeavor. METHODS: We characterized certain elements such as reticulin fibers, collagen type I fibers, and elastic fibers by digital pathology in almost 400 untreated PNB. RESULTS: A reticular and poorly porous ECM was identified in neuroblastomas (NBs) from patients with clinical and biological features associated with poor prognosis compared with a loose and permeable matrix found in NBs of the favorable cohort. CONCLUSIONS: Aggressiveness patterns of ECM can be accurately determined by morphometric tools and could become candidate elements for novel therapies.
Authors: Yiyang Chen; Lina Marie Hoffmeister; Yasmin Zaun; Lucas Arnold; Kurt Werner Schmid; Bernd Giebel; Ludger Klein-Hitpass; Helmut Hanenberg; Anthony Squire; H Christian Reinhardt; Ulrich Dührsen; Stefanie Bertram; Maher Hanoun Journal: Blood Adv Date: 2020-10-27
Authors: Dimakatso Alice Senthebane; Arielle Rowe; Nicholas Ekow Thomford; Hendrina Shipanga; Daniella Munro; Mohammad A M Al Mazeedi; Hashim A M Almazyadi; Karlien Kallmeyer; Collet Dandara; Michael S Pepper; M Iqbal Parker; Kevin Dzobo Journal: Int J Mol Sci Date: 2017-07-21 Impact factor: 5.923
Authors: Pablo Vicente-Munuera; Rebeca Burgos-Panadero; Inmaculada Noguera; Samuel Navarro; Rosa Noguera; Luis M Escudero Journal: Int J Cancer Date: 2019-07-08 Impact factor: 7.396
Authors: Irene Tadeo; Esther Gamero-Sandemetrio; Ana P Berbegall; Marta Gironella; Félix Ritort; Adela Cañete; Gloria Bueno; Samuel Navarro; Rosa Noguera Journal: Oncotarget Date: 2018-05-25
Authors: Amparo López-Carrasco; Susana Martín-Vañó; Rebeca Burgos-Panadero; Ezequiel Monferrer; Ana P Berbegall; Beatriz Fernández-Blanco; Samuel Navarro; Rosa Noguera Journal: J Exp Clin Cancer Res Date: 2020-10-28