S L Percival1. 1. 5D Health Protection Group Ltd, Liverpool Bio-Innovation Hub, William Duncan Building, West Derby Street, Liverpool L7 8TX, UK.
Abstract
BACKGROUND: Biofilms are ubiquitous, and have been observed in both acute and chronic wounds. Their role in wound healing and infection, however, remains controversial. The aim of this review was to provide an overview of the role and relevance of biofilms to surgical wounds. METHODS: A search of PubMed, Science Direct and Web of Science databases was performed to identify studies related to biofilms. Specifically, studies were sought in acute and chronic wounds, and the management and treatment of non-healing and infected skin and wounds. RESULTS: Biofilms may develop in all open wounds. In chronic wounds, biofilms may play a role in prolonging and preventing healing, causing chronic inflammation and increasing the risk of infection. Controversies exist regarding the methods presently employed for biofilm detection and management and few data exist to underpin these decisions. CONCLUSION: Biofilms in acute surgical and chronic wounds appear to cause a delay in healing and potentially increase the risk of infection. Biofilms can be prevented and once developed can be controlled using wound desloughing and debridement.
BACKGROUND: Biofilms are ubiquitous, and have been observed in both acute and chronic wounds. Their role in wound healing and infection, however, remains controversial. The aim of this review was to provide an overview of the role and relevance of biofilms to surgical wounds. METHODS: A search of PubMed, Science Direct and Web of Science databases was performed to identify studies related to biofilms. Specifically, studies were sought in acute and chronic wounds, and the management and treatment of non-healing and infected skin and wounds. RESULTS: Biofilms may develop in all open wounds. In chronic wounds, biofilms may play a role in prolonging and preventing healing, causing chronic inflammation and increasing the risk of infection. Controversies exist regarding the methods presently employed for biofilm detection and management and few data exist to underpin these decisions. CONCLUSION: Biofilms in acute surgical and chronic wounds appear to cause a delay in healing and potentially increase the risk of infection. Biofilms can be prevented and once developed can be controlled using wound desloughing and debridement.
Authors: Wen Yin; Siyang Xu; Yiting Wang; Yuling Zhang; Shan-Ho Chou; Michael Y Galperin; Jin He Journal: Crit Rev Microbiol Date: 2020-12-28 Impact factor: 7.624
Authors: Mara Mădălina Mihai; Mădălina Preda; Iulia Lungu; Monica Cartelle Gestal; Mircea Ioan Popa; Alina Maria Holban Journal: Int J Mol Sci Date: 2018-04-12 Impact factor: 5.923