| Literature DB >> 28120468 |
Jamie E Meegan1, Xiaoyuan Yang1, Danielle C Coleman1, Melanie Jannaway1, Sarah Y Yuan1.
Abstract
Neutrophils play an essential role in host defense against infection or injury. While neutrophil activation is necessary for pathogen clearance and tissue repair, a hyperactive response can lead to tissue damage and microcirculatory disorders, a process involving complex neutrophil-endothelium cross talk. This review highlights recent research findings about neutrophil-mediated signaling and structural changes, including those induced by neutrophil extracellular traps, which ultimately lead to vascular barrier injury.Entities:
Keywords: endothelial barrier dysfunction; neutrophil extracellular traps; vascular hyperpermeability
Mesh:
Year: 2017 PMID: 28120468 PMCID: PMC5404986 DOI: 10.1111/micc.12352
Source DB: PubMed Journal: Microcirculation ISSN: 1073-9688 Impact factor: 2.628