Literature DB >> 28120468

Neutrophil-mediated vascular barrier injury: Role of neutrophil extracellular traps.

Jamie E Meegan1, Xiaoyuan Yang1, Danielle C Coleman1, Melanie Jannaway1, Sarah Y Yuan1.   

Abstract

Neutrophils play an essential role in host defense against infection or injury. While neutrophil activation is necessary for pathogen clearance and tissue repair, a hyperactive response can lead to tissue damage and microcirculatory disorders, a process involving complex neutrophil-endothelium cross talk. This review highlights recent research findings about neutrophil-mediated signaling and structural changes, including those induced by neutrophil extracellular traps, which ultimately lead to vascular barrier injury.
© 2017 John Wiley & Sons Ltd.

Entities:  

Keywords:  endothelial barrier dysfunction; neutrophil extracellular traps; vascular hyperpermeability

Mesh:

Year:  2017        PMID: 28120468      PMCID: PMC5404986          DOI: 10.1111/micc.12352

Source DB:  PubMed          Journal:  Microcirculation        ISSN: 1073-9688            Impact factor:   2.628


  131 in total

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Journal:  J Biol Chem       Date:  2003-02-12       Impact factor: 5.157

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  22 in total

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Review 5.  Role of negative regulation of immune signaling pathways in neutrophil function.

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6.  Toll-like Receptor 4 Signaling and Downstream Neutrophilic Inflammation Mediate Endotoxemia-Enhanced Blood-Labyrinth Barrier Trafficking.

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Review 8.  Role of Neutrophil Extracellular Traps and Vesicles in Regulating Vascular Endothelial Permeability.

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9.  Induction of neutrophil extracellular traps during tissue injury: Involvement of STING and Toll-like receptor 9 pathways.

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10.  Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis.

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