Literature DB >> 2812024

Scanning from an independently specified branch point defines the 3' splice site of mammalian introns.

C W Smith1, E B Porro, J G Patton, B Nadal-Ginard.   

Abstract

During pre-messenger RNA splicing the lariat branch point in mammalian introns is specified independently of the 3' splice site by the sequence surrounding the branch point and by an adjacent downstream polypyrimidine tract. The 3' splice site is dispensable for spliceosome assembly and cleavage at the 5' splice site, and is itself determined by a scanning process that recognizes the first AG located 3' of the branch point/polypyrimidine tract, irrespective of distance or sequence environment.

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Year:  1989        PMID： 2812024     DOI： 10.1038/342243a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  118 in total

1.  Evidence for a linear search in bimolecular 3' splice site AG selection.

Authors:  S Chen; K Anderson; M J Moore
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-18       Impact factor: 11.205

2.  An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing.

Authors:  K Chua; R Reed
Journal:  Mol Cell Biol       Date:  2001-03       Impact factor: 4.272

3.  Role of the 3' splice site in U12-dependent intron splicing.

Authors:  R C Dietrich; M J Peris; A S Seyboldt; R A Padgett
Journal:  Mol Cell Biol       Date:  2001-03       Impact factor: 4.272

4.  SMNrp is an essential pre-mRNA splicing factor required for the formation of the mature spliceosome.

Authors:  G Meister; S Hannus; O Plöttner; T Baars; E Hartmann; S Fakan; B Laggerbauer; U Fischer
Journal:  EMBO J       Date:  2001-05-01       Impact factor: 11.598

Review 5.  Sorting out the complexity of SR protein functions.

Authors:  B R Graveley
Journal:  RNA       Date:  2000-09       Impact factor: 4.942

6.  5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly.

Authors:  Vienna L Reichert; Hervé Le Hir; Melissa S Jurica; Melissa J Moore
Journal:  Genes Dev       Date:  2002-11-01       Impact factor: 11.361

7.  The spliceosome assembly pathway in mammalian extracts.

Authors:  S F Jamison; A Crow; M A Garcia-Blanco
Journal:  Mol Cell Biol       Date:  1992-10       Impact factor: 4.272

8.  Alternative splicing of a human alpha-tropomyosin muscle-specific exon: identification of determining sequences.

Authors:  I R Graham; M Hamshere; I C Eperon
Journal:  Mol Cell Biol       Date:  1992-09       Impact factor: 4.272

9.  Spliced transcripts of human cytomegalovirus.

Authors:  W D Rawlinson; B G Barrell
Journal:  J Virol       Date:  1993-09       Impact factor: 5.103

10.  Abnormal muscle development in the heldup3 mutant of Drosophila melanogaster is caused by a splicing defect affecting selected troponin I isoforms.

Authors:  J A Barbas; J Galceran; L Torroja; A Prado; A Ferrús
Journal:  Mol Cell Biol       Date:  1993-03       Impact factor: 4.272
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