Literature DB >> 28119482

The Emerging Role of Cables1 in Cancer and Other Diseases.

Jia-Rong Huang1, Guang-Mou Tan1, Yong Li1, Zhi Shi2.   

Abstract

Cdk5 and Abl enzyme substrate 1 (Cables1) is an adaptor protein that links cyclin-dependent kinase (Cdks) with nonreceptor tyrosine kinases and regulates the activity of Cdks by enhancing their Y15 phosphorylation. Emerging evidence also shows that Cables1 can interact with, for example, p53 family proteins, 14-3-3, and β-catenin, suggesting that Cables1 may be a signaling hub for the regulation of cell growth. Abnormal expression of Cables1 has been observed in multiple types of cancers and other diseases. In this review, we summarize the characteristics of Cables1 and highlight the molecular mechanisms through which Cables1 regulates the development of cancer and other diseases. Finally, we discuss future challenges in demonstrating the role and potential application of Cables1 in cancer and other diseases.
Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics.

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Year:  2017        PMID： 28119482     DOI： 10.1124/mol.116.107730

Source DB:  PubMed          Journal:  Mol Pharmacol        ISSN： 0026-895X            Impact factor:   4.436


  8 in total

1.  Selective 14-3-3γ Upregulation Promotes Beclin-1-LC3-Autophagic Influx via β-Catenin Interaction in Starved Neurons In Vitro and In Vivo.

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Journal:  Neurochem Res       Date:  2019-01-11       Impact factor: 3.996

Review 2.  Genetics of Cushing's Syndrome.

Authors:  Laura C Hernández-Ramírez; Constantine A Stratakis
Journal:  Endocrinol Metab Clin North Am       Date:  2018-06       Impact factor: 4.741

3.  Genome-wide association analysis identifies new candidate risk loci for familial intracranial aneurysm in the French-Canadian population.

Authors:  Sirui Zhou; Ziv Gan-Or; Amirthagowri Ambalavanan; Dongbing Lai; Pingxing Xie; Cynthia V Bourassa; Stephanie Strong; Jay P Ross; Alexandre Dionne-Laporte; Dan Spiegelman; Nicolas Dupré; Tatiana M Foroud; Lan Xiong; Patrick A Dion; Guy A Rouleau
Journal:  Sci Rep       Date:  2018-03-12       Impact factor: 4.379

4.  CABLES1 Deficiency Impairs Quiescence and Stress Responses of Hematopoietic Stem Cells in Intrinsic and Extrinsic Manners.

Authors:  Liang He; Florian Beghi; Viviane Baral; Mallorie Dépond; Yanyan Zhang; Virginie Joulin; Bo R Rueda; Patrick Gonin; Adlen Foudi; Monika Wittner; Fawzia Louache
Journal:  Stem Cell Reports       Date:  2019-07-18       Impact factor: 7.765

Review 5.  Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications.

Authors:  Sharon Eleuteri; Alessandra Fierabracci
Journal:  Int J Mol Sci       Date:  2019-09-17       Impact factor: 5.923

6.  A quantitative trait locus on chromosome 2 was identified that accounts for a substantial proportion of phenotypic variance of the yellow plumage color in chicken.

Authors:  Tao Huang; Yuejin Pu; Chi Song; Zheya Sheng; Xiaoxiang Hu
Journal:  Poult Sci       Date:  2020-03-05       Impact factor: 3.352

7.  Epigenomic and Transcriptomic Prioritization of Candidate Obesity-Risk Regulatory GWAS SNPs.

Authors:  Xiao Zhang; Tian-Ying Li; Hong-Mei Xiao; Kenneth C Ehrlich; Hui Shen; Hong-Wen Deng; Melanie Ehrlich
Journal:  Int J Mol Sci       Date:  2022-01-23       Impact factor: 5.923

8.  Prenatal diagnosis and genetic counseling of a paternally inherited microduplication 18q11.1 to 18q11.2 in a chinese family.

Authors:  Juan Chen; Ying Zhang; Mingxi Zhang
Journal:  Mol Cytogenet       Date:  2022-09-01       Impact factor: 1.904
  8 in total

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