Julius Burkauskas1, Adomas Bunevicius2, Julija Brozaitiene1, Julius Neverauskas1, Peter Lang3, Robert Duwors3, Narseta Mickuviene1, Robertas Bunevicius1. 1. Behavioral Medicine Institute, Lithuanian University of Health Sciences, Palanga LT-00135, Lithuania. 2. Laboratory of Clinical Research, Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas LT-44307, Lithuania. 3. Harvard Medical School, Laboratory of Clinical & Experimental Psychopathology, Dr John C. Corrigan Mental Health Center, 49 Hillside Street, Fall River, MA 02720, USA.
Abstract
OBJECTIVE: To determine whether biomarkers of health such as serum levels of free triiodothyronine (fT3), total triiodothyronine (TT3), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high-sensitivity C-reactive protein (hsCRP) impact the cognitive functioning of coronary artery disease (CAD) patients. METHOD: About 278 patients were evaluated for socio-demographic and clinical risk factors as well as fT3, TT3, NT-proBNP, and hsCRP serum levels. Cognitive functioning measures included the Mini-Mental State Examination, Digit Span Test, Digit Symbol Substitution Test (DSST), and Trail Making Test A (TMTA). Depressive symptoms were assessed with the Hospital Anxiety and Depression Scale. RESULTS: Lower fT3 concentrations were associated with longer completion time of the DSST and TMTA. Elevated levels of NT-proBNP were also associated with inferior performance on TMTA independently of socio-demographic characteristics, clinical risk factors, and depression symptoms. CONCLUSIONS: Lower fT3 concentrations and higher levels of NT-proBNP were associated with worse cognitive functioning in CAD patients.
OBJECTIVE: To determine whether biomarkers of health such as serum levels of free triiodothyronine (fT3), total triiodothyronine (TT3), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high-sensitivity C-reactive protein (hsCRP) impact the cognitive functioning of coronary artery disease (CAD) patients. METHOD: About 278 patients were evaluated for socio-demographic and clinical risk factors as well as fT3, TT3, NT-proBNP, and hsCRP serum levels. Cognitive functioning measures included the Mini-Mental State Examination, Digit Span Test, Digit Symbol Substitution Test (DSST), and Trail Making Test A (TMTA). Depressive symptoms were assessed with the Hospital Anxiety and Depression Scale. RESULTS: Lower fT3 concentrations were associated with longer completion time of the DSST and TMTA. Elevated levels of NT-proBNP were also associated with inferior performance on TMTA independently of socio-demographic characteristics, clinical risk factors, and depression symptoms. CONCLUSIONS: Lower fT3 concentrations and higher levels of NT-proBNP were associated with worse cognitive functioning in CAD patients.
Authors: Adomas Bunevicius; Vytenis Deltuva; Edward R Laws; Giorgio Iervasi; Arimantas Tamsauskas; Robertas Bunevicius Journal: Sci Rep Date: 2017-11-07 Impact factor: 4.379