Casilda Olveira1, Alicia Padilla2, Miguel-Ángel Martínez-García3, David de la Rosa4, Rosa-María Girón5, Montserrat Vendrell6, Luis Máiz7, Luis Borderías8, Eva Polverino9, Eva Martínez-Moragón10, Olga Rajas11, Francisco Casas12, Rosa Cordovilla13, Javier de Gracia14. 1. Servicio de Neumología, Hospital Regional Universitario de Málaga, Instituto de Biomedicina de Málaga (IBIMA), Facultad de Medicina, Universidad de Málaga, Málaga, España. Electronic address: casi1547@separ.es. 2. Unidad de Neumología, Agencia Sanitaria Costa del Sol, Marbella, Málaga, España. 3. Servicio de Neumología, Hospital Universitario y Politécnico La Fe⋅ CIBER de enfermedades respiratorias (CIBERes), Valencia, España. 4. Unidad de Neumología, Hospital Plató, Barcelona, España. 5. Servicio de Neumología, Instituto de Investigación Sanitaria Hospital Universitario de la Princesa, Madrid, España. 6. Servicio de Neumología, Hospital Josep Trueta⋅ Biomedical Research Institute (IDIBGI), Girona, España. 7. Servicio de Neumología, Hospital Ramón y Cajal, Madrid, España. 8. Servicio de Neumología, Hospital General San Jorge, Huesca, España. 9. Servicio de Neumología, Hospital Clínic i Provincial, Barcelona, España. 10. Servicio de Neumología, Hospital de Sagunto, Sagunto, Valencia, España. 11. Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, Madrid, España. 12. Complejo Hospitalario Universitario de Granada, Granada, España. 13. Servicio de Neumología, Hospital Universitario de Salamanca, Salamanca, España. 14. Servicio de Neumología, Hospital Vall d'Hebron, Barcelona, España.
Abstract
INTRODUCTION: Bronchiectasis is caused by many diseases. Establishing its etiology is important for clinical and prognostic reasons. The aim of this study was to evaluate the etiology of bronchiectasis in a large patient sample and its possible relationship with demographic, clinical or severity factors, and to analyze differences between idiopathic disease, post-infectious disease, and disease caused by other factors. METHODS: Multicenter, cross-sectional study of the SEPAR Spanish Historical Registry (RHEBQ-SEPAR). Adult patients with bronchiectasis followed by pulmonologists were included prospectively. Etiological studies were based on guidelines and standardized diagnostic tests included in the register, which were later included in the SEPAR guidelines on bronchiectasis. RESULTS: A total of 2,047 patients from 36 Spanish hospitals were analyzed. Mean age was 64.9years and 54.9% were women. Etiology was identified in 75.8% of cases (post-Infection: 30%; cystic fibrosis: 12.5%; immunodeficiencies: 9.4%; COPD: 7.8%; asthma: 5.4%; ciliary dyskinesia: 2.9%, and systemic diseases: 1.4%). The different etiologies presented different demographic, clinical, and microbiological factors. Post-infectious bronchiectasis and bronchiectasis caused by COPD and asthma were associated with an increased risk of poorer lung function. Patients with post-infectious bronchiectasis were older and were diagnosed later. Idiopathic bronchiectasis was more common in female non-smokers and was associated with better lung function, a higher body mass index, and a lower rate of Pseudomonas aeruginosa than bronchiectasis of known etiology. CONCLUSIONS: The etiology of bronchiectasis was identified in a large proportion of patients included in the RHEBQ-SEPAR registry. Different phenotypes associated with different causes could be identified.
INTRODUCTION: Bronchiectasis is caused by many diseases. Establishing its etiology is important for clinical and prognostic reasons. The aim of this study was to evaluate the etiology of bronchiectasis in a large patient sample and its possible relationship with demographic, clinical or severity factors, and to analyze differences between idiopathic disease, post-infectious disease, and disease caused by other factors. METHODS: Multicenter, cross-sectional study of the SEPAR Spanish Historical Registry (RHEBQ-SEPAR). Adult patients with bronchiectasis followed by pulmonologists were included prospectively. Etiological studies were based on guidelines and standardized diagnostic tests included in the register, which were later included in the SEPAR guidelines on bronchiectasis. RESULTS: A total of 2,047 patients from 36 Spanish hospitals were analyzed. Mean age was 64.9years and 54.9% were women. Etiology was identified in 75.8% of cases (post-Infection: 30%; cystic fibrosis: 12.5%; immunodeficiencies: 9.4%; COPD: 7.8%; asthma: 5.4%; ciliary dyskinesia: 2.9%, and systemic diseases: 1.4%). The different etiologies presented different demographic, clinical, and microbiological factors. Post-infectious bronchiectasis and bronchiectasis caused by COPD and asthma were associated with an increased risk of poorer lung function. Patients with post-infectious bronchiectasis were older and were diagnosed later. Idiopathic bronchiectasis was more common in female non-smokers and was associated with better lung function, a higher body mass index, and a lower rate of Pseudomonas aeruginosa than bronchiectasis of known etiology. CONCLUSIONS: The etiology of bronchiectasis was identified in a large proportion of patients included in the RHEBQ-SEPAR registry. Different phenotypes associated with different causes could be identified.
Authors: Luis Máiz; Rosa Nieto; Rafael Cantón; Elia Gómez G de la Pedrosa; Miguel Ángel Martinez-García Journal: Int J Mol Sci Date: 2018-01-04 Impact factor: 5.923
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Authors: Mônica Corso Pereira; Rodrigo Abensur Athanazio; Paulo de Tarso Roth Dalcin; Mara Rúbia Fernandes de Figueiredo; Mauro Gomes; Clarice Guimarães de Freitas; Fernando Ludgren; Ilma Aparecida Paschoal; Samia Zahi Rached; Rosemeri Maurici Journal: J Bras Pneumol Date: 2019-08-12 Impact factor: 2.624
Authors: James D Chalmers; Megan Crichton; Pieter C Goeminne; Michael R Loebinger; Charles Haworth; Marta Almagro; Montse Vendrell; Anthony De Soyza; Raja Dhar; Lucy Morgan; Francesco Blasi; Stefano Aliberti; Jeanette Boyd; Eva Polverino Journal: Breathe (Sheff) Date: 2017-09
Authors: Gema Sánchez-Muñoz; Ana Lopez-de-Andrés; Valentín Hernández-Barrera; Rodrigo Jiménez-García; Fernando Pedraza-Serrano; Luis Puente-Maestu; Javier de Miguel-Díez Journal: PLoS One Date: 2019-01-25 Impact factor: 3.240