Literature DB >> 28118933

Integrative medicine: Breaking down silos of knowledge and practice an epigenetic approach.

Bruce S McEwen1.   

Abstract

The future of medicine is discussed in the context of epigenetic influences during the entire life course and the lived experiences of each person, avoiding as much as possible the "medicalization" of the individual and taking a more humanistic view. The reciprocal communication between brain and body via the neuroendocrine, autonomic, metabolic and immune systems and the plasticity of brain architecture provide the basis for devising better "top down" interventions that engage the whole person in working towards his or her welfare. The life course perspective emphasizes the importance of intervening early in life to prevent adverse early life experiences, including the effects of poverty, that can have lifelong consequences, referred to as "biological embedding". In the spirit of integrative, humanistic medicine, treatments that "open windows of plasticity" allow targeted behavioral interventions to redirect brain and body functions and behavior in healthier directions. Policies of government and the private sector, particularly at the local, community level, can create a supporting environment for such interventions. See "Common Ground for Health: Personalized, Precision and Social Medicine McEwen & Getz - https://www.youtube.com/watch?v=IRy_uUWyrEw.
Copyright © 2017. Published by Elsevier Inc.

Entities:  

Keywords:  Adverse childhood experiences; Depression; Humanistic medicine; Multi-morbidity; Resilience

Mesh:

Year:  2017        PMID: 28118933     DOI: 10.1016/j.metabol.2017.01.018

Source DB:  PubMed          Journal:  Metabolism        ISSN: 0026-0495            Impact factor:   8.694


  9 in total

1.  Validation of the Lifetime Total Physical Activity Questionnaire (LTPAQ) in midlife and older adults with a history of late-onset depression.

Authors:  Elisa R Torres
Journal:  Arch Psychiatr Nurs       Date:  2018-03-12       Impact factor: 2.218

2.  Epigenetics and the International Classification of Functioning, Disability and Health Model: Bridging Nature, Nurture, and Patient-Centered Population Health.

Authors:  Richard K Shields; Shauna Dudley-Javoroski
Journal:  Phys Ther       Date:  2022-01-01

3.  THE CREATIVE PSYCHOSOCIAL GENOMIC HEALING EXPERIENCE (CPGHE) AND GENE EXPRESSION IN BREAST CANCER PATIENTS: A FEASIBILITY STUDY.

Authors:  Francisco V Muñoz; Linda Larkey
Journal:  Adv Integr Med       Date:  2018-03-13

4.  Investigation of bidirectional longitudinal associations between advanced epigenetic age and peripheral biomarkers of inflammation and metabolic syndrome.

Authors:  Filomene G Morrison; Mark W Logue; Rachel Guetta; Hannah Maniates; Annjanette Stone; Steven A Schichman; Regina E McGlinchey; William P Milberg; Mark W Miller; Erika J Wolf
Journal:  Aging (Albany NY)       Date:  2019-06-07       Impact factor: 5.682

5.  The Bell Tolls for Homeopathy: Time for Change in the Training and Practice of North American Naturopathic Physicians.

Authors:  David H Nelson; Jaclyn M Perchaluk; Alan C Logan; Martin A Katzman
Journal:  J Evid Based Integr Med       Date:  2019 Jan-Dec

Review 6.  A butterfly flaps its wings: Extinction of biological experience and the origins of allergy.

Authors:  Susan L Prescott
Journal:  Ann Allergy Asthma Immunol       Date:  2020-05-29       Impact factor: 6.347

7.  Earth Dreams: Reimagining ARPA for Health of People, Places and Planet.

Authors:  Alan C Logan; Brian M Berman; Susan L Prescott
Journal:  Int J Environ Res Public Health       Date:  2021-12-03       Impact factor: 3.390

8.  Spaceship Earth Revisited: The Co-Benefits of Overcoming Biological Extinction of Experience at the Level of Person, Place and Planet.

Authors:  Susan L Prescott; Jeffrey S Bland
Journal:  Int J Environ Res Public Health       Date:  2020-02-21       Impact factor: 3.390

9.  ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research.

Authors:  Peter Kochunov; L Elliot Hong; Emily L Dennis; Rajendra A Morey; David F Tate; Elisabeth A Wilde; Mark Logue; Sinead Kelly; Gary Donohoe; Pauline Favre; Josselin Houenou; Christopher R K Ching; Laurena Holleran; Ole A Andreassen; Laura S van Velzen; Lianne Schmaal; Julio E Villalón-Reina; Carrie E Bearden; Fabrizio Piras; Gianfranco Spalletta; Odile A van den Heuvel; Dick J Veltman; Dan J Stein; Meghann C Ryan; Yunlong Tan; Theo G M van Erp; Jessica A Turner; Liz Haddad; Talia M Nir; David C Glahn; Paul M Thompson; Neda Jahanshad
Journal:  Hum Brain Mapp       Date:  2020-04-16       Impact factor: 5.038

  9 in total

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