Joana Ribeiro1,2,3,4, Cláudia Oliveira1,5, Mariana Malta1,5, Hugo Sousa1,2. 1. Molecular Oncology & Viral Pathology Group (CI-IPOP), Portuguese Oncology Institute of Porto (IPO-Porto), Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal. 2. Virology Service, Portuguese Oncology Institute of Porto (IPO-Porto), Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal. 3. Faculty of Medicine of Porto University (FMUP), Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal. 4. Research Department, Portuguese League Against Cancer (Liga Portuguesa Contra o Cancro - Núcleo Regional do Norte), Estrada Interior da Circunvalação 6657, 4200 Porto, Portugal. 5. Abel Salazar Institute for the Biomedical Sciences (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
Abstract
METHODS: A systematic review of literature was conducted to identify all published reports regarding the expression of Epstein-Barr Virus (EBV) proteins/transcripts and EBV latency patterns in EBV-associated gastric carcinomas (EBVaGC). RESULTS: The literature search retrieved 247 papers, of which 25 papers matched the inclusion criteria. The analysis reveals that the most frequently expressed EBV latent proteins are EBNA1 (98.1%) and LMP2A (53.8%), while LMP1 and LMP2B are present in only 10% of cases. Lytic proteins, such as BARF0 and BARF1, and other lytic transcripts are present in almost half of cases. CONCLUSION: EBVaGC seems to display a unique transcription/latency pattern that does not fit the 'standard' EBV latency patterns and therefore should be further studied to better understand EBVaGC carcinogenesis.
METHODS: A systematic review of literature was conducted to identify all published reports regarding the expression of Epstein-Barr Virus (EBV) proteins/transcripts and EBV latency patterns in EBV-associated gastric carcinomas (EBVaGC). RESULTS: The literature search retrieved 247 papers, of which 25 papers matched the inclusion criteria. The analysis reveals that the most frequently expressed EBV latent proteins are EBNA1 (98.1%) and LMP2A (53.8%), while LMP1 and LMP2B are present in only 10% of cases. Lytic proteins, such as BARF0 and BARF1, and other lytic transcripts are present in almost half of cases. CONCLUSION: EBVaGC seems to display a unique transcription/latency pattern that does not fit the 'standard' EBV latency patterns and therefore should be further studied to better understand EBVaGC carcinogenesis.
Authors: Mark A Rider; Mujeeb R Cheerathodi; Stephanie N Hurwitz; Dingani Nkosi; Lauren A Howell; Deanna C Tremblay; Xia Liu; Fanxiu Zhu; David G Meckes Journal: Virology Date: 2018-01-09 Impact factor: 3.616
Authors: M Constanza Camargo; Kyoung-Mee Kim; Keitaro Matsuo; Javier Torres; Linda M Liao; Douglas Morgan; Angelika Michel; Tim Waterboer; Minkyo Song; Margaret L Gulley; Ricardo L Dominguez; Yasushi Yatabe; Sung Kim; Gustavo Cortes-Martinez; Jolanta Lissowska; Jovanny Zabaleta; Michael Pawlita; Charles S Rabkin Journal: Cancer Epidemiol Biomarkers Prev Date: 2019-11-12 Impact factor: 4.254