Josef Briegel1, Thomas Bein, Patrick Möhnle. 1. aKlinik für Anästhesiologie, Klinikum der Universität München, Munich bKlinik für Anästhesiologie, Universitätsklinikum Regensburg, Regensburg, Germany.
Abstract
PURPOSE OF REVIEW: Low-dose hydrocortisone is recommended in patients with septic shock unresponsive to fluid and vasopressor therapy. Recent research added new data for patients with septic shock and other target groups such as patients with severe sepsis, acute respiratory distress syndrome (ARDS), community-acquired pneumonia, and burns. The objective of this review is to summarize and comment recent findings on low-dose corticosteroids (LDC) in critically ill patients. RECENT FINDINGS: In the last 2 years, a series of clinical trials and retrospective analyses investigated LDC therapy in critically ill patients with severe systemic inflammation of various origins. Improvement in morbidity has been demonstrated in ARDS and community-acquired pneumonia. Retrospective propensity-score analyses also suggest that LDC administered in severe septic shock or in septic shock due to community-acquired pneumonia or intestinal perforation may improve survival. SUMMARY: Low-dose hydrocortisone or a corresponding low-dose corticosteroid therapy may improve morbidity in specific target groups of critically ill patients. Beneficial effects on mortality remain to be demonstrated in large-scale randomized controlled trials.
PURPOSE OF REVIEW: Low-dose hydrocortisone is recommended in patients with septic shock unresponsive to fluid and vasopressor therapy. Recent research added new data for patients with septic shock and other target groups such as patients with severe sepsis, acute respiratory distress syndrome (ARDS), community-acquired pneumonia, and burns. The objective of this review is to summarize and comment recent findings on low-dose corticosteroids (LDC) in critically illpatients. RECENT FINDINGS: In the last 2 years, a series of clinical trials and retrospective analyses investigated LDC therapy in critically illpatients with severe systemic inflammation of various origins. Improvement in morbidity has been demonstrated in ARDS and community-acquired pneumonia. Retrospective propensity-score analyses also suggest that LDC administered in severe septic shock or in septic shock due to community-acquired pneumonia or intestinal perforation may improve survival. SUMMARY: Low-dose hydrocortisone or a corresponding low-dose corticosteroid therapy may improve morbidity in specific target groups of critically illpatients. Beneficial effects on mortality remain to be demonstrated in large-scale randomized controlled trials.
Authors: Thomas W L Scheeren; Jan Bakker; Daniel De Backer; Djillali Annane; Pierre Asfar; E Christiaan Boerma; Maurizio Cecconi; Arnaldo Dubin; Martin W Dünser; Jacques Duranteau; Anthony C Gordon; Olfa Hamzaoui; Glenn Hernández; Marc Leone; Bruno Levy; Claude Martin; Alexandre Mebazaa; Xavier Monnet; Andrea Morelli; Didier Payen; Rupert Pearse; Michael R Pinsky; Peter Radermacher; Daniel Reuter; Bernd Saugel; Yasser Sakr; Mervyn Singer; Pierre Squara; Antoine Vieillard-Baron; Philippe Vignon; Simon T Vistisen; Iwan C C van der Horst; Jean-Louis Vincent; Jean-Louis Teboul Journal: Ann Intensive Care Date: 2019-01-30 Impact factor: 6.925