| Literature DB >> 28117588 |
Andrea Astolfi1, Tommaso Felicetti1, Nunzio Iraci1, Giuseppe Manfroni1, Serena Massari1, Donatella Pietrella1, Oriana Tabarrini1, Glenn W Kaatz2, Maria L Barreca1, Stefano Sabatini1, Violetta Cecchetti1.
Abstract
An intriguing opportunity to address antimicrobial resistance is represented by the inhibition of efflux pumps. Focusing on NorA, the most important efflux pump of Staphylococcus aureus, an efflux pump inhibitors (EPIs) library was used for ligand-based pharmacophore modeling studies. By exploitation of the obtained models, an in silico drug repositioning approach allowed for the identification of novel and potent NorA EPIs.Entities:
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Year: 2017 PMID： 28117588 DOI： 10.1021/acs.jmedchem.6b01439
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446