Literature DB >> 28115402

Surgical resection of a rare cutaneous manifestation of Scedosporium apiospermum in a patient who underwent renal transplant.

A C S Stoneham1, S E Stoneham2, S A Wyllie3, A N Pandya4.   

Abstract

A man aged 47 years who was immunosuppressed following renal transplantation for focal segmental glomerulosclerosis was referred to the Plastic Surgery team for management of a painful, chronic, granulomatous lesion of the right forearm. Serial ultrasound scans and MRI scans were not diagnostic, but microbiological specimens tested positive for the fungus Scedosporium apiospermum The renal transplant graft-which was failing-was removed, allowing him to cease immunosuppression. He then underwent a resection of the lesion and reconstruction with a split thickness skin graft. Analysis of the specimen revealed fibrosis, granulomatosis and a collection of S. apiospermum He was started on voriconazole which, in conjunction with his surgical resection, appears to have kept the disease at bay. With increasing numbers of solid organ transplants and improved survival, this case highlights the growing burden of rare, opportunistic infections, the difficulty in diagnosis and the need for specialist intervention. 2017 BMJ Publishing Group Ltd.

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Year:  2017        PMID: 28115402      PMCID: PMC5278337          DOI: 10.1136/bcr-2016-217923

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  14 in total

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Authors:  W B COOKE; P KABLER
Journal:  Public Health Rep       Date:  1955-07       Impact factor: 2.792

Review 2.  Pseudallescheriasis in the 21st century.

Authors:  Thomas A O'Bryan
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3.  The isolation of Aliescheria boydii shear, an etiologic agent of mycetomas, from soil.

Authors:  L AJELLO
Journal:  Am J Trop Med Hyg       Date:  1952-03       Impact factor: 2.345

Review 4.  Fungal skin infections in organ transplant recipients.

Authors:  Annarosa Virgili; Maria Rosaria Zampino; Lucia Mantovani
Journal:  Am J Clin Dermatol       Date:  2002       Impact factor: 7.403

5.  Multicenter clinical evaluation of the (1-->3) beta-D-glucan assay as an aid to diagnosis of fungal infections in humans.

Authors:  Luis Ostrosky-Zeichner; Barbara D Alexander; Daniel H Kett; Jose Vazquez; Peter G Pappas; Fumihiro Saeki; Paul A Ketchum; John Wingard; Robert Schiff; Hiroshi Tamura; Malcolm A Finkelman; John H Rex
Journal:  Clin Infect Dis       Date:  2005-07-21       Impact factor: 9.079

6.  Pseudallescheriasis: a summary of patients from 1980-2003 in a tertiary care center.

Authors:  Yasodah Jayamohan; Julie A Ribes
Journal:  Arch Pathol Lab Med       Date:  2006-12       Impact factor: 5.534

7.  Cutaneous infection due to Scedosporium apiospermum in an immunosuppressed patient.

Authors:  M A Chaveiro; R Vieira; J Cardoso; A Afonso
Journal:  J Eur Acad Dermatol Venereol       Date:  2003-01       Impact factor: 6.166

Review 8.  Infections caused by Scedosporium spp.

Authors:  Karoll J Cortez; Emmanuel Roilides; Flavio Quiroz-Telles; Joseph Meletiadis; Charalampos Antachopoulos; Tena Knudsen; Wendy Buchanan; Jeffrey Milanovich; Deanna A Sutton; Annette Fothergill; Michael G Rinaldi; Yvonne R Shea; Theoklis Zaoutis; Shyam Kottilil; Thomas J Walsh
Journal:  Clin Microbiol Rev       Date:  2008-01       Impact factor: 26.132

Review 9.  Pseudallescheria boydii (Anamorph Scedosporium apiospermum). Infection in solid organ transplant recipients in a tertiary medical center and review of the literature.

Authors:  Barbara Castiglioni; Deanna A Sutton; Michael G Rinaldi; John Fung; Shimon Kusne
Journal:  Medicine (Baltimore)       Date:  2002-09       Impact factor: 1.889

Review 10.  Opportunistic fungal and bacterial infection in the renal transplant recipient.

Authors:  N E Tolkoff-Rubin; R H Rubin
Journal:  J Am Soc Nephrol       Date:  1992-06       Impact factor: 10.121

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  1 in total

Review 1.  Dermatological Complications After Solid Organ Transplantation.

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Journal:  Clin Rev Allergy Immunol       Date:  2018-02       Impact factor: 10.817

  1 in total

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