Literature DB >> 28110483

Explosive Blast Loading on Human 3D Aggregate Minibrains.

Nicole E Zander1, Thuvan Piehler2, Helena Hogberg3, David Pamies3.   

Abstract

The effects of primary explosive blast on brain tissue still remain mostly unknown. There are few in vitro models that use real explosives to probe the mechanisms of injury at the cellular level. In this work, 3D aggregates of human brain cells or brain microphysiological system were exposed to military explosives at two different pressures (50 and 100 psi). Results indicate that membrane damage and oxidative stress increased with blast pressure, but cell death remained minimal.

Entities:  

Keywords:  Explosives; In vitro model; Induced pluripotent stem cells; Minibrain; Primary blast; Traumatic brain injury

Mesh：

Year:  2017        PMID： 28110483     DOI： 10.1007/s10571-017-0463-7

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  9 in total

1.  Studies on blast traumatic brain injury using in-vitro model with shock tube.

Authors:  Peethambaran Arun; John Spadaro; Jennifer John; Robert B Gharavi; Timothy B Bentley; Madhusoodana P Nambiar
Journal:  Neuroreport       Date:  2011-06-11       Impact factor: 1.837

2.  Isolated primary blast alters neuronal function with minimal cell death in organotypic hippocampal slice cultures.

Authors:  Gwen B Effgen; Edward W Vogel; Kimberly A Lynch; Ayelet Lobel; Christopher D Hue; David F Meaney; Cameron R Dale Bass; Barclay Morrison
Journal:  J Neurotrauma       Date:  2014-05-08       Impact factor: 5.269

3.  In vitro studies of primary explosive blast loading on neurons.

Authors:  Nicole E Zander; Thuvan Piehler; Mary E Boggs; Rohan Banton; Richard Benjamin
Journal:  J Neurosci Res       Date:  2015-04-24       Impact factor: 4.164

4.  The effect of explosive blast loading on human neuroblastoma cells.

Authors:  Nicole E Zander; Thuvan Piehler; Rohan Banton; Mary Boggs
Journal:  Anal Biochem       Date:  2016-03-28       Impact factor: 3.365

Review 5.  Biological and medical applications of a brain-on-a-chip.

Authors:  David Pamies; Thomas Hartung; Helena T Hogberg
Journal:  Exp Biol Med (Maywood)       Date:  2014-06-09

6.  Effects of repetitive low-pressure explosive blast on primary neurons and mixed cultures.

Authors:  Nicole E Zander; Thuvan Piehler; Rohan Banton; Richard Benjamin
Journal:  J Neurosci Res       Date:  2016-06-18       Impact factor: 4.164

7.  Shear forces during blast, not abrupt changes in pressure alone, generate calcium activity in human brain cells.

Authors:  Rea Ravin; Paul S Blank; Alex Steinkamp; Shay M Rappaport; Nitay Ravin; Ludmila Bezrukov; Hugo Guerrero-Cazares; Alfredo Quinones-Hinojosa; Sergey M Bezrukov; Joshua Zimmerberg
Journal:  PLoS One       Date:  2012-06-29       Impact factor: 3.240

Review 8.  Toward a 3D model of human brain development for studying gene/environment interactions.

Authors:  Helena T Hogberg; Joseph Bressler; Kimberly M Christian; Georgina Harris; Georgia Makri; Cliona O'Driscoll; David Pamies; Lena Smirnova; Zhexing Wen; Thomas Hartung
Journal:  Stem Cell Res Ther       Date:  2013-12-20       Impact factor: 6.832

9.  A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity.

Authors:  David Pamies; Paula Barreras; Katharina Block; Georgia Makri; Anupama Kumar; Daphne Wiersma; Lenna Smirnova; Ce Zang; Joseph Bressler; Kimberly M Christian; Georgina Harris; Guo-Li Ming; Cindy J Berlinicke; Kelly Kyro; Hongjun Song; Carlos A Pardo; Thomas Hartung; Helena T Hogberg
Journal:  ALTEX       Date:  2016-11-24       Impact factor: 6.043
  9 in total
  9 in total

1.  Rotenone exerts developmental neurotoxicity in a human brain spheroid model.

Authors:  David Pamies; Katharina Block; Pierre Lau; Laura Gribaldo; Carlos A Pardo; Paula Barreras; Lena Smirnova; Daphne Wiersma; Liang Zhao; Georgina Harris; Thomas Hartung; Helena T Hogberg
Journal:  Toxicol Appl Pharmacol       Date:  2018-02-08       Impact factor: 4.219

2.  Military blast-induced synaptic changes with distinct vulnerability may explain behavioral alterations in the absence of obvious brain damage.

Authors:  Catherine M Parisian; Gregory Georgevitch; Ben A Bahr
Journal:  J Nat Sci       Date:  2017-07

3.  Studying Human Neurological Disorders Using Induced Pluripotent Stem Cells: From 2D Monolayer to 3D Organoid and Blood Brain Barrier Models.

Authors:  Sarah Logan; Thiago Arzua; Scott G Canfield; Emily R Seminary; Samantha L Sison; Allison D Ebert; Xiaowen Bai
Journal:  Compr Physiol       Date:  2019-03-14       Impact factor: 9.090

4.  Current ex Vivo and in Vitro Approaches to Uncovering Mechanisms of Neurological Dysfunction after Traumatic Brain Injury.

Authors:  Kelly Andrew Hamilton; Vijayalakshmi Santhakumar
Journal:  Curr Opin Biomed Eng       Date:  2020-05-11

5.  Human IPSC 3D brain model as a tool to study chemical-induced dopaminergic neuronal toxicity.

Authors:  David Pamies; Daphne Wiersma; Moriah E Katt; Liang Zhao; Johannes Burtscher; Georgina Harris; Lena Smirnova; Peter C Searson; Thomas Hartung; Helena T Hogberg
Journal:  Neurobiol Dis       Date:  2022-04-07       Impact factor: 7.046

6.  Blast Preconditioning Protects Retinal Ganglion Cells and Reveals Targets for Prevention of Neurodegeneration Following Blast-Mediated Traumatic Brian Injury.

Authors:  Matthew M Harper; Addison W Woll; Lucy P Evans; Michael Delcau; Abhigna Akurathi; Adam Hedberg-Buenz; Dana A Soukup; Nickolas Boehme; Marco M Hefti; Laura M Dutca; Michael G Anderson; Alexander G Bassuk
Journal:  Invest Ophthalmol Vis Sci       Date:  2019-10-01       Impact factor: 4.799

7.  Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery.

Authors:  Paulo Emílio Corrêa Leite; Mariana Rodrigues Pereira; Georgina Harris; David Pamies; Lisia Maria Gobbo Dos Santos; José Mauro Granjeiro; Helena T Hogberg; Thomas Hartung; Lena Smirnova
Journal:  Part Fibre Toxicol       Date:  2019-06-03       Impact factor: 9.400

Review 8.  The Emergence of Model Systems to Investigate the Link Between Traumatic Brain Injury and Alzheimer's Disease.

Authors:  Gayathri Srinivasan; David A Brafman
Journal:  Front Aging Neurosci       Date:  2022-02-08       Impact factor: 5.750

Review 9.  The Role of BDNF in Experimental and Clinical Traumatic Brain Injury.

Authors:  David Gustafsson; Andrea Klang; Sebastian Thams; Elham Rostami
Journal:  Int J Mol Sci       Date:  2021-03-30       Impact factor: 5.923
  9 in total

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