OBJECTIVES: To test the association of low-grade inflammation with socioeconomic status (SES) and determine the relative contribution of prevalent chronic diseases and health-related behaviours in explaining such association. METHODS: Cross-sectional analysis on 19,867 subjects (age ≥35, 48.1% men) recruited within the Moli-sani study from 2005 to 2010 (Italy). A score of low-grade inflammation, including platelet and leukocyte counts, the granulocyte-to-lymphocyte ratio, and C-reactive protein was applied. SES was measured by education, household income, and occupational social class. RESULTS: Low SES was associated with elevated levels of low-grade inflammation. Health behaviours (including adiposity, smoking, physical activity, and Mediterranean diet adherence) explained 53.5, 53.9, and 84.9% of the association between social class, income, and education with low-grade inflammation, respectively. Adiposity and body mass index showed a prominent role, while prevalent chronic diseases and conditions only marginally attenuated SES inequalities in inflammation. CONCLUSIONS: Low-grade inflammation was socioeconomically patterned in a large Mediterranean population. Potentially modifiable behavioural factors explained the greatest part of this association with a leading contribution of adiposity, body mass index, and physical activity.
OBJECTIVES: To test the association of low-grade inflammation with socioeconomic status (SES) and determine the relative contribution of prevalent chronic diseases and health-related behaviours in explaining such association. METHODS: Cross-sectional analysis on 19,867 subjects (age ≥35, 48.1% men) recruited within the Moli-sani study from 2005 to 2010 (Italy). A score of low-grade inflammation, including platelet and leukocyte counts, the granulocyte-to-lymphocyte ratio, and C-reactive protein was applied. SES was measured by education, household income, and occupational social class. RESULTS: Low SES was associated with elevated levels of low-grade inflammation. Health behaviours (including adiposity, smoking, physical activity, and Mediterranean diet adherence) explained 53.5, 53.9, and 84.9% of the association between social class, income, and education with low-grade inflammation, respectively. Adiposity and body mass index showed a prominent role, while prevalent chronic diseases and conditions only marginally attenuated SES inequalities in inflammation. CONCLUSIONS: Low-grade inflammation was socioeconomically patterned in a large Mediterranean population. Potentially modifiable behavioural factors explained the greatest part of this association with a leading contribution of adiposity, body mass index, and physical activity.
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Authors: Lucie M Turcotte; Tao Wang; Michael T Hemmer; Stephen R Spellman; Mukta Arora; Daniel Couriel; Amin Alousi; Joseph Pidala; Hisham Abdel-Azim; Ibrahim Ahmed; Amer Beitinjaneh; David Buchbinder; Michael Byrne; Natalie Callander; Nelson Chao; Sung Wong Choi; Zachariah DeFilipp; Shahinaz M Gadalla; Robert Peter Gale; Usama Gergis; Shahrukh Hashmi; Peiman Hematti; Leona Holmberg; Yoshihiro Inamoto; Rammurti T Kamble; Leslie Lehmann; Margaret A MacMillan; Zachariah McIver; Taiga Nishihori; Maxim Norkin; Tracey O'Brien; Richard F Olsson; Ran Reshef; Ayman Saad; Bipin N Savani; Harry C Schouten; Sachiko Seo; Melhem Solh; Leo Verdonck; Ravi Vij; Baldeep Wirk; Jean Yared; Mary M Horowitz; Jennifer M Knight; Michael R Verneris Journal: Bone Marrow Transplant Date: 2018-01-30 Impact factor: 5.483