Seiji Shiota1, Aaron P Thrift2, Linda Green3, Rajesh Shah1, Gordana Verstovsek3, Massimo Rugge4, David Y Graham1, Hashem B El-Serag5. 1. Section of Gastroenterology and Hepatology, Michael E. DeBakey VA Medical Center, Houston, Texas; Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas. 2. Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas. 3. Department of Pathology, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas. 4. Surgical Pathology & Cytopathology Unit, Department of Medicine-DIMED, University of Padova, Padova, Italy; Casa Sollievo della Sofferenza, Department of Pathology, San Giovanni Rotondo, Italy. 5. Section of Gastroenterology and Hepatology, Michael E. DeBakey VA Medical Center, Houston, Texas; Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas; Houston VA HSR&D Center for Innovations in Quality, Effectiveness and Safety, Houston, Texas. Electronic address: hasheme@bcm.edu.
Abstract
BACKGROUND & AIMS: There are data to suggest the existence of non-Helicobacter pylori gastritis. However, the risk factors and clinical course for H pylori-negative gastritis remain unclear. We aimed to examine the prevalence and determinants of H pylori-negative gastritis in a large multiethnic clinical population. METHODS: We conducted a cross-sectional study among patents scheduled for an elective esophagastroduodenoscopy or attending selected primary care clinics and eligible for screening colonoscopy at a single Veterans Affairs medical center. We identified cases of H pylor-negative gastritis, H pylori-positive gastritis, and H pylori-negative nongastritis, where gastritis was defined by the presence of neutrophils and/or mononuclear cells. Risk factors for H pylori-negative gastritis were analyzed in logistic regression models. RESULTS: A total of 1240 patients had information from all biopsy sites, of whom 695 (56.0%) had gastritis. H pylori-negative gastritis was present in 123 patients (9.9% of all study subjects and 17.7% of all patients with gastritis). Among all patients with gastritis, African Americans were statistically significantly less likely than non-Hispanic whites to have H pylori-negative gastritis (odds ratio, 0.25; 95% confidence interval, 0.14-0.43). Conversely, PPI users were more likely to have H pylori-negative gastritis than H pylori-positive gastritis compared with nonusers (odds ratio, 2.02; 95% confidence interval, 1.17-3.49). The cumulative incidence of gastric erosions and ulcers were higher in patients with H pylori-negative gastritis than H pylori-negative nongastritis. CONCLUSIONS: We found that H pylori-negative gastritis was present in approximately 18% of patients with gastritis. The potential for H pylori-negative gastritis to progress or the risk of gastric cancer of those with gastric mucosal atrophy/intestinal metaplasia remains unclear.
BACKGROUND & AIMS: There are data to suggest the existence of non-Helicobacter pylorigastritis. However, the risk factors and clinical course for H pylori-negative gastritis remain unclear. We aimed to examine the prevalence and determinants of H pylori-negative gastritis in a large multiethnic clinical population. METHODS: We conducted a cross-sectional study among patents scheduled for an elective esophagastroduodenoscopy or attending selected primary care clinics and eligible for screening colonoscopy at a single Veterans Affairs medical center. We identified cases of H pylor-negative gastritis, H pylori-positive gastritis, and H pylori-negative nongastritis, where gastritis was defined by the presence of neutrophils and/or mononuclear cells. Risk factors for H pylori-negative gastritis were analyzed in logistic regression models. RESULTS: A total of 1240 patients had information from all biopsy sites, of whom 695 (56.0%) had gastritis. H pylori-negative gastritis was present in 123 patients (9.9% of all study subjects and 17.7% of all patients with gastritis). Among all patients with gastritis, African Americans were statistically significantly less likely than non-Hispanic whites to have H pylori-negative gastritis (odds ratio, 0.25; 95% confidence interval, 0.14-0.43). Conversely, PPI users were more likely to have H pylori-negative gastritis than H pylori-positive gastritis compared with nonusers (odds ratio, 2.02; 95% confidence interval, 1.17-3.49). The cumulative incidence of gastric erosions and ulcers were higher in patients with H pylori-negative gastritis than H pylori-negative nongastritis. CONCLUSIONS: We found that H pylori-negative gastritis was present in approximately 18% of patients with gastritis. The potential for H pylori-negative gastritis to progress or the risk of gastric cancer of those with gastric mucosal atrophy/intestinal metaplasia remains unclear.
Authors: Theresa H Nguyen; Niharika Mallepally; Tariq Hammad; Yan Liu; Aaron P Thrift; Hashem B El-Serag; Mimi C Tan Journal: Dig Dis Sci Date: 2019-11-14 Impact factor: 3.199
Authors: Jung Won Lee; Nayoung Kim; Ji Hyun Park; Hee Jin Kim; Hyun Chang; Jung Min Kim; Jin-Wook Kim; Dong Ho Lee Journal: J Cancer Prev Date: 2017-03-30
Authors: Muhammad Miftahussurur; Langgeng Agung Waskito; Ari Fahrial Syam; Iswan Abbas Nusi; I Dewa Nyoman Wibawa; Yudith Annisa Ayu Rezkitha; Gontar Siregar; O K Yulizal; Fardah Akil; Willy Brodus Uwan; David Simanjuntak; Jimmy Bradley Waleleng; Alexander Michael Joseph Saudale; Fauzi Yusuf; Hasan Maulahela; Marselino Richardo; Abdul Rahman; Yoma Sari Namara; Eko Sudarmo; Pangestu Adi; Ummi Maimunah; Poernomo Boedi Setiawan; Kartika Afrida Fauzia; Dalla Doohan; Tomohisa Uchida; Maria Inge Lusida; Yoshio Yamaoka Journal: PLoS One Date: 2019-05-09 Impact factor: 3.240