| Literature DB >> 28109909 |
Kailash Chandra Mangalhara1, Siddharth Manvati2, Sunil Kumar Saini1, Kalaiarasan Ponnusamy2, Gaurav Agarwal3, Suresh K Abraham1, Rameshwar N K Bamezai4.
Abstract
Regulation of metastasis continues to remain enigmatic despite our improved understanding of cancer. Identification of microRNAs associated with metastasis in the recent past has provided a new hope. Here, we show how microRNA-101 (miR-101) regulates two independent processes of cellular metastasis by targeting pro-metastatic upstream regulatory transcription factors, ZEB1 and ZEB2, and downstream effector-actin modulators, RHOA and RAC1, providing a single target for therapeutic intervention. Further, we depict how down-regulation of miR-101 by extracellular signal-regulated kinase-2 (ERK2) is vital for MAP kinase pathway induced cellular migration and mesenchymal transition. Importantly, EKR2 induced expression of ZEB1 seems essential for down-regulation of miR-101-1 and induction of EMT. Given the role of EMT in metastasis, we also observe a significant correlation between miR-101 expression and lymph node metastasis; and identify the ERK2-ZEB1-miR-101-1 pathway active in breast cancer tissues, with an apparent clinicopathological implication.Entities:
Keywords: Breast cancer; Cytoskeleton; EMT-TFs; Epidermal growth factor (EGF); miR-101; microRNA
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Year: 2017 PMID： 28109909 DOI： 10.1016/j.canlet.2017.01.016
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679