Bi-Yong Qin1, Li-Lei Dai, Yan Zheng. 1. Department of Neurology, People's Hospital Affiliated to Hubei University of Medicine, Shiyan 442000, China.E-mail: Beyondqby@163.com.
Abstract
OBJECTIVE: To assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) for alleviating the clinical symptoms and suicidal ideation in elderly patients with depression. METHODS: A total of 178 elderly depressive patients with suicidal ideation were randomized into rTMS treatment group (n=80) and control group (n=98) and treated with rTMS or sham rTMS treatment for 4 weeks in addition to conventional therapy with medications. The 24-item Hamilton Depression Scales (HAMD) and Self-rating Idea of Suicide Scale (SIOSS) were used to assess the severity of depression and the risk of suicide at the baseline and after 2 and 4 weeks of treatment. The treatment response was defined as a 25% reduction in HAMD scores from baseline, and an early improvement as 20% reduction in HAMD scores after 2 weeks of treatment. RESULTS: The two groups of patients were comparable for baseline socio-demographic characteristics and baseline SIOSS and HAMD scores (P>0.05). After 2 and 4 weeks of treatment, both SIOSS and HAMD scores were improved in the two groups, but the patients in rTMS group showed a significantly faster score reduction. A significantly higher rate of early improvement at 2 weeks (52.5% vs 28.6%; χ2=10.569, P<0.01) and a higher response rate at 4 weeks (77.5% vs 53.1%; χ2=15.470, P<0.05) were observed in rTMS group. CONCLUSIONS:rTMS combined with medications can effectively improve sleep quality, cognitive impairment and somatization symptom and reduce suicidal ideation in elderly patients with depression.
RCT Entities:
OBJECTIVE: To assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) for alleviating the clinical symptoms and suicidal ideation in elderly patients with depression. METHODS: A total of 178 elderly depressivepatients with suicidal ideation were randomized into rTMS treatment group (n=80) and control group (n=98) and treated with rTMS or sham rTMS treatment for 4 weeks in addition to conventional therapy with medications. The 24-item Hamilton Depression Scales (HAMD) and Self-rating Idea of Suicide Scale (SIOSS) were used to assess the severity of depression and the risk of suicide at the baseline and after 2 and 4 weeks of treatment. The treatment response was defined as a 25% reduction in HAMD scores from baseline, and an early improvement as 20% reduction in HAMD scores after 2 weeks of treatment. RESULTS: The two groups of patients were comparable for baseline socio-demographic characteristics and baseline SIOSS and HAMD scores (P>0.05). After 2 and 4 weeks of treatment, both SIOSS and HAMD scores were improved in the two groups, but the patients in rTMS group showed a significantly faster score reduction. A significantly higher rate of early improvement at 2 weeks (52.5% vs 28.6%; χ2=10.569, P<0.01) and a higher response rate at 4 weeks (77.5% vs 53.1%; χ2=15.470, P<0.05) were observed in rTMS group. CONCLUSIONS: rTMS combined with medications can effectively improve sleep quality, cognitive impairment and somatization symptom and reduce suicidal ideation in elderly patients with depression.
Authors: Claudia Cooper; Cornelius Katona; Kostas Lyketsos; Dan Blazer; Henry Brodaty; Peter Rabins; Carlos Augusto de Mendonça Lima; Gill Livingston Journal: Am J Psychiatry Date: 2011-03-31 Impact factor: 18.112
Authors: A L Beautrais; P R Joyce; R T Mulder; D M Fergusson; B J Deavoll; S K Nightingale Journal: Am J Psychiatry Date: 1996-08 Impact factor: 18.112
Authors: Sidney H Kennedy; Roumen Milev; Peter Giacobbe; Rajamannar Ramasubbu; Raymond W Lam; Sagar V Parikh; Scott B Patten; Arun V Ravindran Journal: J Affect Disord Date: 2009-08-05 Impact factor: 4.839
Authors: Mark S George; Rema Raman; David M Benedek; Christopher G Pelic; Geoffrey G Grammer; Karen T Stokes; Matthew Schmidt; Chad Spiegel; Nancy Dealmeida; Kathryn L Beaver; Jeffrey J Borckardt; Xiaoying Sun; Sonia Jain; Murray B Stein Journal: Brain Stimul Date: 2014-03-19 Impact factor: 8.955
Authors: Nolan R Williams; Boris D Heifets; Brandon S Bentzley; Christine Blasey; Keith D Sudheimer; Jessica Hawkins; David M Lyons; Alan F Schatzberg Journal: Mol Psychiatry Date: 2019-08-29 Impact factor: 15.992
Authors: Andrea R Collins; Joseph Cheung; Paul E Croarkin; Bhanu Prakash Kolla; Simon Kung Journal: J Clin Sleep Med Date: 2022-05-01 Impact factor: 4.324
Authors: Melanie L Bozzay; Jennifer M Primack; Hannah R Swearingen; Jennifer Barredo; Noah S Philip Journal: Trials Date: 2020-11-12 Impact factor: 2.279
Authors: Leandro Valiengo; Bianca S Pinto; Kalian A P Marinho; Leonardo A Santos; Luara C Tort; Rafael G Benatti; Bruna B Teixeira; Cristiane S Miranda; Henriette B Cardeal; Paulo J C Suen; Julia C Loureiro; Renata A R Vaughan; Roberta A M P F Dini Mattar; Maíra Lessa; Pedro S Oliveira; Valquíria A Silva; Wagner Farid Gattaz; André R Brunoni; Orestes Vicente Forlenza Journal: Front Hum Neurosci Date: 2022-08-31 Impact factor: 3.473
Authors: Ranran Zheng; Mingyang Yu; Li Huang; Fang Wang; Baizhi Gao; Duanduan Fu; Jinghui Zhu; Guilin Liu Journal: Front Public Health Date: 2022-10-03
Authors: Mohamed A Abdelnaim; Berthold Langguth; Markus Deppe; Alexey Mohonko; Peter M Kreuzer; Timm B Poeppl; Tobias Hebel; Martin Schecklmann Journal: Front Psychiatry Date: 2020-01-08 Impact factor: 4.157