A Arroyo1, P Moya2, M A Rodríguez-Prieto3, M J Alcaide4, M M Aguilar4, M Bellón4, M T Pérez-Vázquez2, F Candela4, R Calpena2. 1. Coloproctology Unit, Department of Surgery, General University Hospital of Elche, C/ Camí de l´Almazara. No 11, 03203, Elche, Spain. arroyocir@hotmail.com. 2. Department of Pathology and Surgery, School of Medicine, Miguel Hernandez University, Elche, Spain. 3. Department of Dermatology, University Hospital of Leon, Leon, Spain. 4. Coloproctology Unit, Department of Surgery, General University Hospital of Elche, C/ Camí de l´Almazara. No 11, 03203, Elche, Spain.
Abstract
BACKGROUND: Photodynamic therapy (PDT) is a new procedure for the treatment of anal fistula. This preliminary study was designed to investigate the safety and effectiveness of this new technique in the treatment of anal fistula. METHODS: Ten patients were treated with PDT. Intralesional 5-aminolevulinic acid (ALA) 2% was directly injected into the fistula. The internal and external orifices were closed. After an incubation period of 2 h, the fistula was irradiated using an optical fibre connected to a red laser (MULTIDIODE 630 PDT, INTERmedic, Spain) operating at 1 W/cm for 3 min (180 Joules). Patient demographics, operation notes and complications were recorded. RESULTS: There were no complications. The average length of patient follow-up was 14.9 months (range 12-20 months). We could observe primary healing in eight patients (80%). Two patients (20%) showed persistence of suppuration after the operation. No patient reported incontinence postoperatively. CONCLUSIONS: PDT is a potential sphincter-saving procedure that is safe, simple and minimally invasive and has a high success rate.
BACKGROUND: Photodynamic therapy (PDT) is a new procedure for the treatment of anal fistula. This preliminary study was designed to investigate the safety and effectiveness of this new technique in the treatment of anal fistula. METHODS: Ten patients were treated with PDT. Intralesional 5-aminolevulinic acid (ALA) 2% was directly injected into the fistula. The internal and external orifices were closed. After an incubation period of 2 h, the fistula was irradiated using an optical fibre connected to a red laser (MULTIDIODE 630 PDT, INTERmedic, Spain) operating at 1 W/cm for 3 min (180 Joules). Patient demographics, operation notes and complications were recorded. RESULTS: There were no complications. The average length of patient follow-up was 14.9 months (range 12-20 months). We could observe primary healing in eight patients (80%). Two patients (20%) showed persistence of suppuration after the operation. No patient reported incontinence postoperatively. CONCLUSIONS: PDT is a potential sphincter-saving procedure that is safe, simple and minimally invasive and has a high success rate.
Authors: Yolanda Gilaberte; Carlos Serra-Guillén; María Elena de las Heras; Ricardo Ruiz-Rodríguez; Manuel Fernández-Lorente; Cristiane Benvenuto-Andrade; Salvador González-Rodríguez; Carlos Guillén-Barona Journal: Actas Dermosifiliogr Date: 2006-03
Authors: L M Valladares-Narganes; M A Rodríguez-Prieto; M D Blanco-Suárez; C Rodriguez-Lage; I García-Doval Journal: Br J Dermatol Date: 2015-02-25 Impact factor: 9.302
Authors: Antonio Arroyo; Juan Pérez-Legaz; Pedro Moya; Laura Armañanzas; Javier Lacueva; Francisco Pérez-Vicente; Fernando Candela; Rafael Calpena Journal: Ann Surg Date: 2012-05 Impact factor: 12.969