Paraskevi G Liaveri1, Dimitris Dikeos2, Ioannis Ilias3, Eirini P Lygkoni4, Ioannis N Boletis5, Chryssanthi Skalioti5, Thomas Paparrigopoulos2. 1. Dialysis Unit, "Protypo Nefrologiko Kentro Attikis", Athens, Greece. Electronic address: paraskeviliaveri@yahoo.com. 2. Sleep Research Unit, First Department of Psychiatry, National and Kapodistrian University of Athens, Medical School, "Eginition" Hospital, Athens, Greece. 3. Endocrine Unit, "Elena Venizelou" Hospital, Athens, Greece. 4. School of Applied Mathematics and Physical Science, National Technical University of Athens, Athens, Greece. 5. Nephrology Department, Renal Transplantation Unit, "Laikon" Hospital, Athens, Greece.
Abstract
BACKGROUND: Sleep disorders are very common in patients with chronic kidney disease and they may not always subside after kidney transplantation. AIM AND METHODS: The aim of this cross-sectional study was to evaluate the self-reported quality of sleep, insomnia problems in particular, and examine the factors that disturb sleep of kidney transplant recipients (KTx: n=152) in comparison to age- and sex-matched patients on dialysis (HD: n=67) and participants with normal renal function (NOR: n=49), through the administration of the Athens Insomnia Scale (AIS) at least six months after transplantation. Clinical and laboratory data, as well as health-related quality of life, depression, anxiety, post-traumatic stress symptoms, and the presence of restless legs syndrome (RLS) and pruritus were investigated in relation to sleep problems. RESULTS: The highest mean AIS score was observed in the transplant patients (KTx: 4.6±13.3 vs. HD: 3.8±8.1 vs. NOR: 2.4±10.2); both KTx and HD patients had a lower quality of sleep compared to participants with normal renal function. Multiple linear regression analysis showed that the determinants of the total AIS score were the frequency of post-traumatic stress symptoms, depression, RLS, diastolic blood pressure, and pain (all p<0.0001). CONCLUSION: Although amelioration of renal function post-transplantation improves several aspects of quality of life, it does not seem to have a beneficial effect on self-reported sleep.
BACKGROUND:Sleep disorders are very common in patients with chronic kidney disease and they may not always subside after kidney transplantation. AIM AND METHODS: The aim of this cross-sectional study was to evaluate the self-reported quality of sleep, insomnia problems in particular, and examine the factors that disturb sleep of kidney transplant recipients (KTx: n=152) in comparison to age- and sex-matched patients on dialysis (HD: n=67) and participants with normal renal function (NOR: n=49), through the administration of the Athens Insomnia Scale (AIS) at least six months after transplantation. Clinical and laboratory data, as well as health-related quality of life, depression, anxiety, post-traumatic stress symptoms, and the presence of restless legs syndrome (RLS) and pruritus were investigated in relation to sleep problems. RESULTS: The highest mean AIS score was observed in the transplant patients (KTx: 4.6±13.3 vs. HD: 3.8±8.1 vs. NOR: 2.4±10.2); both KTx and HDpatients had a lower quality of sleep compared to participants with normal renal function. Multiple linear regression analysis showed that the determinants of the total AIS score were the frequency of post-traumatic stress symptoms, depression, RLS, diastolic blood pressure, and pain (all p<0.0001). CONCLUSION: Although amelioration of renal function post-transplantation improves several aspects of quality of life, it does not seem to have a beneficial effect on self-reported sleep.
Authors: Makayla Cordoza; Brittany Koons; Michael L Perlis; Brian J Anderson; Joshua M Diamond; Barbara Riegel Journal: Transplant Rev (Orlando) Date: 2021-09-14 Impact factor: 3.943
Authors: Rebekah P Nash; Marci M Loiselle; Jessica L Stahl; Jamie L Conklin; Terra L Rose; Alissa Hutto; Donna M Evon; Jennifer E Flythe; Eileen J Burker Journal: Kidney360 Date: 2022-08-01