Fang Fang1, Ke Ni2, Yiting Cai1, Jin Shang1, Xiaoke Zhang1, Chengliang Xiong3. 1. Family Planning Research Institute, Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. 2. Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. 3. Family Planning Research Institute, Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China; Wuhan Tongji Reproductive Medicine Hospital, Wuhan, People's Republic of China. Electronic address: clxiong951@sina.com.
Abstract
OBJECTIVE: To evaluate the effect of vitamin D supplementation on patients with PCOS. METHODS: We performed a literature search in database and identified all of the RCTs published before December 2015 that compared the effect of vitamin D supplementation with placebo or metformin in PCOS patients. MAIN RESULTS: Nine out of 463 identified studies were included, involving 502 women presenting with PCOS. Vitamin D supplementation had significant effect on the improvement of follicular development with a higher number of dominant follicles (OR, 2.34; 95% CI, 1.39 to 3.92). Differences in regular menstrual cycles were also observed when metformin plus vitamin D was compared with metformin alone (OR, 1.85; 95% CI, 1.01 to 3.39). CONCLUSIONS: Evidence from available RCTs suggests vitamin D supplementation may be beneficial for follicular development and menstrual cycle regulation in patients with PCOS. Additional high-quality RCTs are required to confirm the effectiveness of vitamin D on PCOS.
OBJECTIVE: To evaluate the effect of vitamin D supplementation on patients with PCOS. METHODS: We performed a literature search in database and identified all of the RCTs published before December 2015 that compared the effect of vitamin D supplementation with placebo or metformin in PCOSpatients. MAIN RESULTS: Nine out of 463 identified studies were included, involving 502 women presenting with PCOS. Vitamin D supplementation had significant effect on the improvement of follicular development with a higher number of dominant follicles (OR, 2.34; 95% CI, 1.39 to 3.92). Differences in regular menstrual cycles were also observed when metformin plus vitamin D was compared with metformin alone (OR, 1.85; 95% CI, 1.01 to 3.39). CONCLUSIONS: Evidence from available RCTs suggests vitamin D supplementation may be beneficial for follicular development and menstrual cycle regulation in patients with PCOS. Additional high-quality RCTs are required to confirm the effectiveness of vitamin D on PCOS.
Authors: Samantha F Butts; David B Seifer; Nathanael Koelper; Suneeta Senapati; Mary D Sammel; Andrew N Hoofnagle; Andrea Kelly; Steven A Krawetz; Nanette Santoro; Heping Zhang; Michael P Diamond; Richard S Legro Journal: J Clin Endocrinol Metab Date: 2019-02-01 Impact factor: 5.958
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