Literature DB >> 2810436

The effects of cadmium, mercury and lead in vitro on hepatic microsomal mixed function oxidase and lipid peroxidation.

G H Xiao, J L Wu, Y G Liu.   

Abstract

In this study, the authors investigated the effect of cadmium, mercury and lead in vitro on hepatic microsomal mixed function oxidase and lipid peroxidation. The results showed that these metals could inhibit the activity of hepatic microsomal aniline hydroxylase, decrease the concentration of hepatic microsomal cytochrome P-450 and increase the concentration of the inactive form of hemoprotein, P-420. Besides, they could enhance hepatic microsomal lipid peroxidation. There were marked concentration-dependent responses in these microsomal reactions. Thus, it may be suggested that cadmium, mercury and lead are capable of impairing hepatic microsomal mixed function oxidase in vitro by stimulating membrane lipid peroxidation.

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Year:  1989        PMID： 2810436     DOI： 10.1007/bf02908931

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  11 in total

1.  THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.

Authors:  T OMURA; R SATO
Journal:  J Biol Chem       Date:  1964-07       Impact factor: 5.157

2.  Destruction of microsomal cytochrome P-450 and glucose-6-phosphatase by lipids extracted from peroxidized microsomes.

Authors:  A M Hruszkewycz; E A Glende; R O Recknagel
Journal:  Toxicol Appl Pharmacol       Date:  1978-12       Impact factor: 4.219

3.  Cytochrome P-450 as a microsomal peroxidase utilizing a lipid peroxide substrate.

Authors:  E G Hrycay; P J O'Brien
Journal:  Arch Biochem Biophys       Date:  1971-11       Impact factor: 4.013

4.  The effects of adriamycin in vitro and in vivo on hepatic microsomal drug-metabolizing enzymes: role of microsomal lipid peroxidation.

Authors:  E G Mimnaugh; M A Trush; E Ginsburg; Y Hirokata; T E Gram
Journal:  Toxicol Appl Pharmacol       Date:  1981-12       Impact factor: 4.219

5.  Effects of linoleic acid hydroperoxide on the hepatic monooxygenase systems of microsomes from untreated, phenobarbital-treated, and 3-methylcholanthrene-treated rats.

Authors:  E Jeffery; A Kotake; R E Azhary
Journal:  Mol Pharmacol       Date:  1977-05       Impact factor: 4.436

6.  Cellular toxicity and lipid peroxidation in response to mercury.

Authors:  N H Stacey; H Kappus
Journal:  Toxicol Appl Pharmacol       Date:  1982-03-30       Impact factor: 4.219

7.  Low level chemiluminescence of liver microsomal fractions initiated by tert-butyl hydroperoxide. Relation to microsomal hemoproteins, oxygen dependence, and lipid peroxidation.

Authors:  E Cadenas; H Sies
Journal:  Eur J Biochem       Date:  1982-05-17

8.  Effects of some toxic metals on hepatic microsomal mixed function oxidase system of the rat.

Authors:  G H Xiao; R K Song; Y G Liu
Journal:  Acta Acad Med Wuhan       Date:  1984

9.  Cadmium toxicity and lipid peroxidation in isolated rat hepatocytes.

Authors:  N H Stacey; L R Cantilena; C D Klaassen
Journal:  Toxicol Appl Pharmacol       Date:  1980-05       Impact factor: 4.219

10.  Effects of trivalent and hexavalent chromium on lipid peroxidation in rat liver microsomes.

Authors:  M Yonaha; Y Ohbayashi; N Noto; E Itoh; M Uchiyama
Journal:  Chem Pharm Bull (Tokyo)       Date:  1980-03       Impact factor: 1.645
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  2 in total

1.  The association between occupational lead exposure and serum cholesterol and lipoprotein levels.

Authors:  E Kristal-Boneh; D Coller; P Froom; G Harari; J Ribak
Journal:  Am J Public Health       Date:  1999-07       Impact factor: 9.308

2.  Lipid abnormalities in rats given small doses of lead.

Authors:  A Skoczyńska; R Smolik; M Jeleń
Journal:  Arch Toxicol       Date:  1993       Impact factor: 5.153
  2 in total

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