Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Resisting the Urge to Act: DREADDs Modifying Habits.

Literature DB >> 28104285

Resisting the Urge to Act: DREADDs Modifying Habits.

Abstract

Recently, Meyer and Bucci used chemogenetic technology - artificial excitatory and inhibitory receptors - to modulate neuronal activity in two connected brain regions in opposite directions simultaneously. This innovative manipulation revealed that the two regions studied, orbitofrontal cortex and nucleus accumbens, are not sequentially dependent during contextual decision-making. Published by Elsevier Ltd.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2017 PMID： 28104285 PMCID： PMC5285454 DOI： 10.1016/j.tins.2016.12.002

Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837

Keyword Cloud
References

10 in total

1. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.

Authors: Blaine N Armbruster; Xiang Li; Mark H Pausch; Stefan Herlitze; Bryan L Roth
Journal: Proc Natl Acad Sci U S A Date: 2007-03-02 Impact factor: 11.205

2. The adolescent brain.

Authors: B J Casey; Sarah Getz; Adriana Galvan
Journal: Dev Rev Date: 2008

3. Expression of transgenes in midbrain dopamine neurons using the tyrosine hydroxylase promoter.

Authors: M S Oh; S J Hong; Y Huh; K-S Kim
Journal: Gene Ther Date: 2008-09-18 Impact factor: 5.250

4. A Social Neuroscience Perspective on Adolescent Risk-Taking.

Authors: Laurence Steinberg
Journal: Dev Rev Date: 2008-03

Review 5. DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility.

Authors: Daniel J Urban; Bryan L Roth
Journal: Annu Rev Pharmacol Toxicol Date: 2014-09-25 Impact factor: 13.820

10. Clozapine N-Oxide Administration Produces Behavioral Effects in Long-Evans Rats: Implications for Designing DREADD Experiments.

Authors: Duncan A A MacLaren; Richard W Browne; Jessica K Shaw; Sandhya Krishnan Radhakrishnan; Prachi Khare; Rodrigo A España; Stewart D Clark
Journal: eNeuro Date: 2016-11-01

10 in total

Resisting the Urge to Act: DREADDs Modifying Habits.

1. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.

2. The adolescent brain.

3. Expression of transgenes in midbrain dopamine neurons using the tyrosine hydroxylase promoter.

4. A Social Neuroscience Perspective on Adolescent Risk-Taking.

Review 5. DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility.

6. A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse.

7. Imbalanced Activity in the Orbitofrontal Cortex and Nucleus Accumbens Impairs Behavioral Inhibition.

8. Chemogenetic synaptic silencing of neural circuits localizes a hypothalamus→midbrain pathway for feeding behavior.

9. Combined use of the canine adenovirus-2 and DREADD-technology to activate specific neural pathways in vivo.

10. Clozapine N-Oxide Administration Produces Behavioral Effects in Long-Evans Rats: Implications for Designing DREADD Experiments.