BACKGROUND: Deficits in instrumental activities of daily living (ADLs) may be more prominent in behavioral variant frontotemporal dementia (bvFTD) than in nonfluent/agrammatic variant primary progressive aphasia (nfvPPA) or semantic variant primary progressive aphasia (svPPA). It is uncertain whether frontotemporal dementia (FTD) subgroups exhibit different patterns and/or predictors of functional impairment. METHODS: We examined data from participants diagnosed with bvFTD (n = 607), svPPA (n = 132), and nfvPPA (n = 155) who were included in the National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) and assessed with the Functional Activities Questionnaire (FAQ). Stepwise multiple linear regression analyses were performed to identify associations between FAQ scores and cognitive/behavioral deficits using the NACC UDS neuropsychological testing battery and the Neuropsychiatric Inventory Questionnaire. RESULTS: FAQ scores were higher in bvFTD than svPPA or nfvPPA. Functional deficits across FTD subtypes differed in severity, but not pattern, and were driven by executive dysfunction and behavioral symptoms. CONCLUSION: Executive dysfunction and behavioral symptoms underlie instrumental ADL deficits in FTD, which are most prominent in bvFTD.
BACKGROUND:Deficits in instrumental activities of daily living (ADLs) may be more prominent in behavioral variant frontotemporal dementia (bvFTD) than in nonfluent/agrammatic variant primary progressive aphasia (nfvPPA) or semantic variant primary progressive aphasia (svPPA). It is uncertain whether frontotemporal dementia (FTD) subgroups exhibit different patterns and/or predictors of functional impairment. METHODS: We examined data from participants diagnosed with bvFTD (n = 607), svPPA (n = 132), and nfvPPA (n = 155) who were included in the National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) and assessed with the Functional Activities Questionnaire (FAQ). Stepwise multiple linear regression analyses were performed to identify associations between FAQ scores and cognitive/behavioral deficits using the NACC UDS neuropsychological testing battery and the Neuropsychiatric Inventory Questionnaire. RESULTS: FAQ scores were higher in bvFTD than svPPA or nfvPPA. Functional deficits across FTD subtypes differed in severity, but not pattern, and were driven by executive dysfunction and behavioral symptoms. CONCLUSION: Executive dysfunction and behavioral symptoms underlie instrumental ADL deficits in FTD, which are most prominent in bvFTD.
Authors: J C Morris; A Heyman; R C Mohs; J P Hughes; G van Belle; G Fillenbaum; E D Mellits; C Clark Journal: Neurology Date: 1989-09 Impact factor: 9.910
Authors: Mariel B Deutsch; Li-Jung Liang; Elvira E Jimenez; Michelle J Mather; Mario F Mendez Journal: Int Psychogeriatr Date: 2016-04-15 Impact factor: 3.878
Authors: Claire M O'Connor; Lindy Clemson; Michael Hornberger; Cristian E Leyton; John R Hodges; Olivier Piguet; Eneida Mioshi Journal: Neurol Clin Pract Date: 2016-10
Authors: Mônica S Yassuda; Thais B Lima da Silva; Claire M O'Connor; Shailaja Mekala; Suvarna Alladi; Valeria S Bahia; Viviane Amaral-Carvalho; Henrique C Guimaraes; Paulo Caramelli; Marcio L F Balthazar; Benito Damasceno; Sonia M D Brucki; Ricardo Nitrini; John R Hodges; Olivier Piguet; Eneida Mioshi Journal: Neurol Clin Pract Date: 2018-04
Authors: Christopher B Morrow; Jeannie-Marie Sheppard Leoutsakos; Chiadi U Onyike Journal: Am J Geriatr Psychiatry Date: 2021-07-28 Impact factor: 7.996
Authors: Clarissa Giebel; Sarah Robertson; Audrey Beaulen; Sandra Zwakhalen; Dawn Allen; Hilde Verbeek Journal: Int J Environ Res Public Health Date: 2021-11-22 Impact factor: 3.390