Literature DB >> 28102083

Development and characterization of morin hydrate loaded microemulsion for the management of Alzheimer's disease.

Dheeraj Sharma1, Manpreet Singh1, Punnet Kumar2, Vir Vikram3, Neeraj Mishra1.   

Abstract

The aim of this study is to prepare and characterize intranasal delivery of morin hydrate loaded microemulsion for the management of Alzheimer's diseases. After intranasal delivery, brain and blood drug concentrations were found to be higher for optimized morin hydrate loaded microemulsion as compared to plain morin hydrate. Significant (P < 0.05) reduction in assessed pharmacodynamic parameters was observed after intranasal administration of morin hydrate loaded microemulsion as compared to sham control group. Daily chronic treatment with morin loaded microemulsion till the 21st day significantly increased the memory in wistar rats with STZ-induced dementia.

Entities:  

Keywords:  Neurofibrillary tangles; amyloid β-peptide; blood–brain barrier; microemulsion; surfactant and cosurfactant ratio (Smix)

Mesh：

Substances：

Year:  2017        PMID： 28102083     DOI： 10.1080/21691401.2016.1276919

Source DB:  PubMed          Journal:  Artif Cells Nanomed Biotechnol        ISSN： 2169-1401            Impact factor:   5.678


  8 in total

1.  Morin Attenuates Neurochemical Changes and Increased Oxidative/Nitrergic Stress in Brains of Mice Exposed to Ketamine: Prevention and Reversal of Schizophrenia-Like Symptoms.

Authors:  Benneth Ben-Azu; Adegbuyi Oladele Aderibigbe; Aya-Ebi Okubo Eneni; Abayomi Mayowa Ajayi; Solomon Umukoro; Ezekiel O Iwalewa
Journal:  Neurochem Res       Date:  2018-06-28       Impact factor: 3.996

2.  Enhancement of Cholinesterase Inhibition of Alpinia galanga (L.) Willd. Essential Oil by Microemulsions.

Authors:  Wantida Chaiyana; Suwannee Sriyab; Siriporn Okonogi
Journal:  Molecules       Date:  2022-05-19       Impact factor: 4.927

3.  Inclusion of a Phytomedicinal Flavonoid in Biocompatible Surface-Modified Chylomicron Mimic Nanovesicles with Improved Oral Bioavailability and Virucidal Activity: Molecular Modeling and Pharmacodynamic Studies.

Authors:  Mohamed Y Zakaria; Paris E Georghiou; Joseph H Banoub; Botros Y Beshay
Journal:  Pharmaceutics       Date:  2022-04-21       Impact factor: 6.525

Review 4.  Polyphenols with Anti-Amyloid β Aggregation Show Potential Risk of Toxicity Via Pro-Oxidant Properties.

Authors:  Hatasu Kobayashi; Mariko Murata; Shosuke Kawanishi; Shinji Oikawa
Journal:  Int J Mol Sci       Date:  2020-05-18       Impact factor: 5.923

5.  Perspective: Therapeutic Potential of Flavonoids as Alternative Medicines in Epilepsy.

Authors:  Jae Young Kwon; Min-Tae Jeon; Un Ju Jung; Dong Woon Kim; Gyeong Joon Moon; Sang Ryong Kim
Journal:  Adv Nutr       Date:  2019-09-01       Impact factor: 8.701

Review 6.  Microemulsion-Based Media in Nose-to-Brain Drug Delivery.

Authors:  Anna Froelich; Tomasz Osmałek; Barbara Jadach; Vinam Puri; Bozena Michniak-Kohn
Journal:  Pharmaceutics       Date:  2021-02-02       Impact factor: 6.321

7.  Neuroprotective Effects of Phytochemicals against Aluminum Chloride-Induced Alzheimer's Disease through ApoE4/LRP1, Wnt3/β-Catenin/GSK3β, and TLR4/NLRP3 Pathways with Physical and Mental Activities in a Rat Model.

Authors:  Ahmed Mohsen Elsaid Hamdan; Fatimah Hussain J Alharthi; Ahmed Hadi Alanazi; Soad Z El-Emam; Sameh S Zaghlool; Kamel Metwally; Sana Abdulaziz Albalawi; Yahia S Abdu; Reda El-Sayed Mansour; Hoda A Salem; Zakaria Y Abd Elmageed; Karema Abu-Elfotuh
Journal:  Pharmaceuticals (Basel)       Date:  2022-08-17

8.  Morin inhibits Listeria monocytogenes virulence in vivo and in vitro by targeting listeriolysin O and inflammation.

Authors:  Gen Li; Guizhen Wang; Meng Li; Li Li; Hongtao Liu; Meiyang Sun; Zhongmei Wen
Journal:  BMC Microbiol       Date:  2020-05-12       Impact factor: 3.605
  8 in total

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