Z H Yu1, X H Xu1, S D Wang2, M F Song1, Y Liu1, Y Yin1, H J Mao1, G Z Tang1. 1. Hangzhou Seventh People's Hospital, Hangzhou, 310013, China. 2. Hangzhou Seventh People's Hospital, Hangzhou, 310013, China. wangsd0108@sina.com.
Abstract
PURPOSE:Primary insomnia is a persistent and recurrent disorder as well as a risk factor for depression. The aim of this study was to determine whether the zolpidem combined with paroxetine would be effective in the treatment of patients with primary insomnia. METHODS:Ninety patients meeting DSM-IV criteria for primary insomnia were randomly assigned to 8 weeks of treatment with zolpidem combined with paroxetine (the combined treatment group, n = 45) or zolpidem combined with placebo (the control group, n = 45). Patients were assessed with the Pittsburgh Sleep Quality Index (PSQI), polysomnography (PSG), and the Treatment Emergent Symptom Scale (TESS). RESULTS: Compared with the control group, the combined treatment group was more significantly improved on wake time after sleep onset (WASO), total sleep time (TST), sleep efficiency (SE), and total PSQI scores, but not the sleep onset latency (SOL). CONCLUSIONS: Eight weeks of the zolpidem combined with paroxetine treatment to patients with primary insomnia is more effective than zolpidem treatment only in sleep maintenance and early morning awakenings.
RCT Entities:
PURPOSE:Primary insomnia is a persistent and recurrent disorder as well as a risk factor for depression. The aim of this study was to determine whether the zolpidem combined with paroxetine would be effective in the treatment of patients with primary insomnia. METHODS: Ninety patients meeting DSM-IV criteria for primary insomnia were randomly assigned to 8 weeks of treatment with zolpidem combined with paroxetine (the combined treatment group, n = 45) or zolpidem combined with placebo (the control group, n = 45). Patients were assessed with the Pittsburgh Sleep Quality Index (PSQI), polysomnography (PSG), and the Treatment Emergent Symptom Scale (TESS). RESULTS: Compared with the control group, the combined treatment group was more significantly improved on wake time after sleep onset (WASO), total sleep time (TST), sleep efficiency (SE), and total PSQI scores, but not the sleep onset latency (SOL). CONCLUSIONS: Eight weeks of the zolpidem combined with paroxetine treatment to patients with primary insomnia is more effective than zolpidem treatment only in sleep maintenance and early morning awakenings.
Entities:
Keywords:
PSQI; Polysomnography; Primary insomnia; Zolpidem combined with paroxetine
Authors: Yun Li; Alexandros N Vgontzas; Julio Fernandez-Mendoza; Edward O Bixler; Yuanfeng Sun; Junying Zhou; Rong Ren; Tao Li; Xiangdong Tang Journal: Hypertension Date: 2015-01-26 Impact factor: 10.190
Authors: F Hohagen; R F Montero; E Weiss; S Lis; E Schönbrunn; H Dressing; D Riemann; M Berger Journal: Eur Arch Psychiatry Clin Neurosci Date: 1994 Impact factor: 5.270