Literature DB >> 28101221

A complex translocation (3;17;15) in acute promyelocytic leukemia confirmed by fluorescence in situ hybridization.

Yanming Wang1, Junjie Ma2, Xinguang Liu3, Riming Liu2, Lingling Xu2, Li Wang2, Jiannong Cen4, Xiaoxia Chu2.   

Abstract

Acute promyelocytic leukemia (APL) is typified by t(15;17)(q22;q21), generating the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid α-receptor (RARA) gene at 17q21. The PML-RARA fusion gene is believed to play a vital role in leukemogenesis. A sizeable minority of patients with complex variants of APL have been reported. The present study reports the case of a 33-year-old male with APL carrying a potential complex translocation. The initial symptom was bleeding gums. Chromosomal analysis of the bone marrow cells revealed an atypical 17q aberration. Fluorescence in situ hybridization further indicated that 92% of analyzed cells were positive for the PML-RARA fusion gene. The patient experienced complete remission following treatment with arsenic trioxide and chemotherapy. The atypical translocations in acute promyelocytic leukemia require further investigation.

Entities:  

Keywords:  acute promyelocytic leukemia; complex translocation; t(3,15,17)

Year:  2016        PMID： 28101221      PMCID： PMC5228300          DOI： 10.3892/ol.2016.5280

Source DB:  PubMed          Journal:  Oncol Lett        ISSN： 1792-1074            Impact factor:   2.967


  30 in total

1.  Complex chromosome translocations of standard t(8;21) and t(15;17) arise from a two-step mechanism as evidenced by fluorescence in situ hybridization analysis.

Authors:  G Calabrese; T Min; L Stuppia; R Powles; J G Swansbury; E Morizio; R Peila; E Donti; G Fioritoni; G Palka
Journal:  Cancer Genet Cytogenet       Date:  1996-10-01

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Journal:  Leukemia       Date:  1996-10       Impact factor: 11.528

3.  Complex translocations involving chromosomes 15 and 17 in acute promyelocytic leukaemia.

Authors:  R Bernstein; B Mendelow; M R Pinto; G Morcom; W Bezwoda
Journal:  Br J Haematol       Date:  1980-10       Impact factor: 6.998

Review 4.  Acute promyelocytic leukemia: from highly fatal to highly curable.

Authors:  Zhen-Yi Wang; Zhu Chen
Journal:  Blood       Date:  2008-03-01       Impact factor: 22.113

5.  Acute promyelocytic leukemia with t(15;17) and t(2;17;15).

Authors:  O W Bjerrum; P Philip; T Pressler; I Tygstrup
Journal:  Cancer Genet Cytogenet       Date:  1987-09

6.  Cytogenetic and molecular analysis of an unusual case of acute promyelocytic leukemia with a t(15;17;17)(q22;q23;q21).

Authors:  C A Tirado; V Golembiewski-Ruiz; J Horvatinovich; J O Moore; P J Buckley; T T Stenzel; B K Goodman
Journal:  Cancer Genet Cytogenet       Date:  2003-08

7.  RARA and PML gene rearrangements in acute promyelocytic leukemia with complex translocations and atypical features.

Authors:  C D McKinney; W L Golden; N W Gemma; S H Swerdlow; M E Williams
Journal:  Genes Chromosomes Cancer       Date:  1994-01       Impact factor: 5.006

8.  A complex translocation in acute promyelocytic leukemia.

Authors:  D F Callen; B M Dale; R E Sage; J H Ford
Journal:  Cancer Genet Cytogenet       Date:  1985-03-01

9.  Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.

Authors:  J M Bennett; D Catovsky; M T Daniel; G Flandrin; D A Galton; H R Gralnick; C Sultan
Journal:  Br J Haematol       Date:  1976-08       Impact factor: 6.998

10.  Cytogenetic and molecular characterization of complex three-way translocations in acute promyelocytic leukemia.

Authors:  Christopher E Freeman; Danielle D Mercer; Yi Ye; John Van Brunt; Marilyn M Li
Journal:  Beijing Da Xue Xue Bao Yi Xue Ban       Date:  2009-08-18
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  2 in total

Review 1.  Atypical Rearrangements in APL-Like Acute Myeloid Leukemias: Molecular Characterization and Prognosis.

Authors:  Luca Guarnera; Tiziana Ottone; Emiliano Fabiani; Mariadomenica Divona; Arianna Savi; Serena Travaglini; Giulia Falconi; Paola Panetta; Maria Cristina Rapanotti; Maria Teresa Voso
Journal:  Front Oncol       Date:  2022-04-12       Impact factor: 5.738

2.  Treatment Outcome and the Genetic Characteristics of Acute Promyelocytic Leukemia in Children in Poland From 2005 to 2018.

Authors:  Małgorzata Czogała; Katarzyna Pawińska-Wa Sikowska; Teofila Ksia Żek; Barbara Sikorska-Fic; Michał Matysiak; Anna Rodziewicz-Konarska; Alicja Chybicka; Jolanta Skalska-Sadowska; Jacek Wachowiak; Katarzyna Muszyńska-Rosłan; Maryna Krawczuk-Rybak; Dominik Grabowski; Jerzy Kowalczyk; Karolina Zielezińska; Tomasz Urasiński; Renata Tomaszewska; Tomasz Szczepański; Irena Karpińska-Derda; Mariola Woszczyk; Joanna Pohorecka; Grażyna Karolczyk; Wojciech Młynarski; Katarzyna Mycko; Wanda Badowska; Szymon Skoczeń; Walentyna Balwierz
Journal:  Front Pediatr       Date:  2020-03-20       Impact factor: 3.418
  2 in total

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