Jason Chen1, Jin-Tai Yu1, Kevin Wojta1, Hui-Fu Wang1, Henrik Zetterberg1, Kaj Blennow1, Jennifer S Yokoyama1, Michael W Weiner1, Joel H Kramer1, Howard Rosen1, Bruce L Miller1, Giovanni Coppola1, Adam L Boxer2. 1. From the Department of Neurology (J.C., K.W., G.C.), David Geffen School of Medicine, and Memory and Aging Center (J.S.Y., J.H.K., H.R., B.L.M., A.L.B.), Department of Neurology, University of California, Los Angeles; Department of Neurology (J.-T.Y., H.-F.W.), Qingdao Municipal Hospital, Nanjing Medical University, China; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg Mölndal, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, London, UK; and Center for Imaging of Neurodegenerative Diseases (M.W.W.), VAMC San Francisco, CA. 2. From the Department of Neurology (J.C., K.W., G.C.), David Geffen School of Medicine, and Memory and Aging Center (J.S.Y., J.H.K., H.R., B.L.M., A.L.B.), Department of Neurology, University of California, Los Angeles; Department of Neurology (J.-T.Y., H.-F.W.), Qingdao Municipal Hospital, Nanjing Medical University, China; Clinical Neurochemistry Laboratory (H.Z., K.B.), Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg Mölndal, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, London, UK; and Center for Imaging of Neurodegenerative Diseases (M.W.W.), VAMC San Francisco, CA. adam.boxer@ucsf.edu.
Abstract
OBJECTIVE: To identify genetic loci associated with plasma tau concentrations in healthy elders and individuals with Alzheimer disease. METHODS: Four hundred sixty-three non-Hispanic white individuals exceeding quality control criteria were included from the Alzheimer's Disease Neuroimaging Initiative (ADNI-1) cohort. Association of plasma tau with genetic polymorphisms was performed with a linear regression model. Significant associations were validated in an independent replication cohort consisting of 431 healthy elders or individuals with mild cognitive impairment recruited from the University of California, San Francisco Memory and Aging Center. RESULTS: The minor allele (A) of rs242557 in the microtubule-associated protein tau gene (MAPT) was associated with higher plasma tau levels at genome-wide significance (p = 4.85 × 10-9, empiric family-wise error corrected p = 0.0024) in a dose-dependent fashion. This association was also observed in the replication cohort (p = 1.0 × 10-5; joint analysis p = 1.2 × 10-12). Single nucleotide polymorphisms near PARK2 (rs2187213) (p = 6.15 × 10-6), IL2RA (rs7072793, rs7073236) (p = 7.89 × 10-6), and an intergenic locus on 9p21.3 (rs7047280) (p = 8.13 × 10-6) were identified as suggestive loci associated with plasma tau levels. CONCLUSIONS: MAPT H1c haplotype (rs242557) has previously been identified as a genetic risk factor for progressive supranuclear palsy and corticobasal degeneration. The current findings suggest that plasma tau concentration could be an endophenotype for identifying risk for 4-repeat tauopathies in older individuals.
OBJECTIVE: To identify genetic loci associated with plasma tau concentrations in healthy elders and individuals with Alzheimer disease. METHODS: Four hundred sixty-three non-Hispanic white individuals exceeding quality control criteria were included from the Alzheimer's Disease Neuroimaging Initiative (ADNI-1) cohort. Association of plasma tau with genetic polymorphisms was performed with a linear regression model. Significant associations were validated in an independent replication cohort consisting of 431 healthy elders or individuals with mild cognitive impairment recruited from the University of California, San Francisco Memory and Aging Center. RESULTS: The minor allele (A) of rs242557 in the microtubule-associated protein tau gene (MAPT) was associated with higher plasma tau levels at genome-wide significance (p = 4.85 × 10-9, empiric family-wise error corrected p = 0.0024) in a dose-dependent fashion. This association was also observed in the replication cohort (p = 1.0 × 10-5; joint analysis p = 1.2 × 10-12). Single nucleotide polymorphisms near PARK2 (rs2187213) (p = 6.15 × 10-6), IL2RA (rs7072793, rs7073236) (p = 7.89 × 10-6), and an intergenic locus on 9p21.3 (rs7047280) (p = 8.13 × 10-6) were identified as suggestive loci associated with plasma tau levels. CONCLUSIONS:MAPT H1c haplotype (rs242557) has previously been identified as a genetic risk factor for progressive supranuclear palsy and corticobasal degeneration. The current findings suggest that plasma tau concentration could be an endophenotype for identifying risk for 4-repeat tauopathies in older individuals.
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