Hye Jeong Kim1, Ji Cheol Bae2, Hyeong Kyu Park1, Dong Won Byun1, Kyoil Suh1, Myung Hi Yoo1, Jee Jae Hwan3, Jae Hyeon Kim4, Yong-Ki Min4, Sun Wook Kim4, Jae Hoon Chung4. 1. Division of Endocrinology and MetabolismDepartment of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea. 2. Division of Endocrinology and MetabolismDepartment of Medicine, Changwon Samsung Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea. 3. Department of Health Promotion CenterSamsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. 4. Division of Endocrinology and MetabolismDepartment of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Abstract
BACKGROUND: Several cross-sectional studies have reported that thyroid hormone levels are associated with cardiovascular risk markers and metabolic syndrome (MetS) even in euthyroid subjects. However, the prognostic role of serum thyroid hormone levels in the risk of incident MetS has not been elucidated. AIM: We aimed to investigate the associations of baseline serum thyroid hormone levels with the development of MetS in healthy subjects. METHODS: This 6-year, cross-sectional, longitudinal and follow-up study was conducted in 12 037 euthyroid middle-aged subjects without MetS subjected to comprehensive health examinations. Subjects were grouped according to total triiodothyronine (T3) quartiles. The hazard ratio (HR) for the development of MetS according to T3 quartiles was estimated using Cox proportional hazards model. RESULTS: During the 6-year period, 3544 incident cases of MetS (29%) were identified. The proportion of subjects with incident MetS increased across the T3 quartiles (P for trend <0.001). The HR and 95% confidence interval (CI) for the development of MetS were significantly higher in the highest T3 quartile compared with the lowest T3 quartile even after adjusting for confounding variables including gender, age and smoking (HR: 1.238, 95% CI: 1.128-1.358, P < 0.001). CONCLUSION: In euthyroid middle-aged subjects, serum T3 levels are associated with increased risk for future development of MetS.
BACKGROUND: Several cross-sectional studies have reported that thyroid hormone levels are associated with cardiovascular risk markers and metabolic syndrome (MetS) even in euthyroid subjects. However, the prognostic role of serum thyroid hormone levels in the risk of incident MetS has not been elucidated. AIM: We aimed to investigate the associations of baseline serum thyroid hormone levels with the development of MetS in healthy subjects. METHODS: This 6-year, cross-sectional, longitudinal and follow-up study was conducted in 12 037 euthyroid middle-aged subjects without MetS subjected to comprehensive health examinations. Subjects were grouped according to total triiodothyronine (T3) quartiles. The hazard ratio (HR) for the development of MetS according to T3 quartiles was estimated using Cox proportional hazards model. RESULTS: During the 6-year period, 3544 incident cases of MetS (29%) were identified. The proportion of subjects with incident MetS increased across the T3 quartiles (P for trend <0.001). The HR and 95% confidence interval (CI) for the development of MetS were significantly higher in the highest T3 quartile compared with the lowest T3 quartile even after adjusting for confounding variables including gender, age and smoking (HR: 1.238, 95% CI: 1.128-1.358, P < 0.001). CONCLUSION: In euthyroid middle-aged subjects, serum T3 levels are associated with increased risk for future development of MetS.
Authors: Bruce H R Wolffenbuttel; Hanneke J C M Wouters; Sandra N Slagter; Robert P van Waateringe; Anneke C Muller Kobold; Jana V van Vliet-Ostaptchouk; Thera P Links; Melanie M van der Klauw Journal: BMC Endocr Disord Date: 2017-10-16 Impact factor: 2.763